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Association of PHB 1630 C > T and MTHFR 677 C > T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study

Authors :
Jakubowska, A
Rozkrut, D
Antoniou, A
Hamann, U
Scott, RJ
McGuffog, L
Healy, S
Sinilnikova, OM
Rennert, G
Lejbkowicz, F
Flugelman, A
Andrulis, IL
Glendon, G
Ozcelik, H
Thomassen, Marga
Paligo, M
Aretini, P
Kantala, J
Aroer, B
von Wachenfeldt, A
Liljegren, A
Loman, N
Herbst, K
Kristoffersson, U
Rosenquist, R
Karlsson, P
Stenmark-Askmalm, M
Melin, B
Nathanson, KL
Domchek, SM
Byrski, T
Huzarski, T
Gronwald, J
Menkiszak, J
Cybulski, C
Serrano, P
Osorio, A
Cajal, TR
Tsitlaidou, M
Benitez, J
Gilbert, M
Rookus, M
Aalfs, CM
Kluijt, I
Boessenkool-Pape, JL
Meijers-Heijboer, HEJ
Oosterwijk, JC
van Asperen, CJ
Blok, MJ
Nelen, MR
van den Ouweland, Ans
Seynaeve, Caroline
van der Luijt, RB
Devilee, P
Easton, DF
Peock, S
Frost, D
Platte, R
Ellis, SD
Fineberg, E
Evans, DG
Lalloo, F
Eeles, R
Jacobs, C
Adlard, J
Davidson, R
Eccles, D
Cole, T
Cook, J
Godwin, A
Bove, B
Stoppa-Lyonnet, D
Caux-Moncoutier, V
Belotti, M
Tirapo, C
Mazoyer, S
Barjhoux, L
Boutry-Kryza, N
Pujol, P
Coupier, I
Peyrat, JP
Vennin, P
Muller, D
Fricker, JP
Venat-Bouvet, L
Johannsson, O
Isaacs, C
Schmutzler, R
Wappenschmidt, B
Meindl, A
Arnold, N
Varon-Mateeva, R
Niederacher, D
Sutter, C
Deissler, H
Preisler-Adams, S
Simard, J
Soucy, P
Durocher, F
Chenevix-Trench, G
Beesley, J
Chen, X
Rebbeck, T
Couch, F
Wang, X
Lindor, N
Fredericksen, Z
Pankratz, VS
Peterlongo, P
Bonanni, B
Fortuzzi, S
Peissel, B
Szabo, C
Mai, PL
Loud, JT
Lubinski, J
Jakubowska, A
Rozkrut, D
Antoniou, A
Hamann, U
Scott, RJ
McGuffog, L
Healy, S
Sinilnikova, OM
Rennert, G
Lejbkowicz, F
Flugelman, A
Andrulis, IL
Glendon, G
Ozcelik, H
Thomassen, Marga
Paligo, M
Aretini, P
Kantala, J
Aroer, B
von Wachenfeldt, A
Liljegren, A
Loman, N
Herbst, K
Kristoffersson, U
Rosenquist, R
Karlsson, P
Stenmark-Askmalm, M
Melin, B
Nathanson, KL
Domchek, SM
Byrski, T
Huzarski, T
Gronwald, J
Menkiszak, J
Cybulski, C
Serrano, P
Osorio, A
Cajal, TR
Tsitlaidou, M
Benitez, J
Gilbert, M
Rookus, M
Aalfs, CM
Kluijt, I
Boessenkool-Pape, JL
Meijers-Heijboer, HEJ
Oosterwijk, JC
van Asperen, CJ
Blok, MJ
Nelen, MR
van den Ouweland, Ans
Seynaeve, Caroline
van der Luijt, RB
Devilee, P
Easton, DF
Peock, S
Frost, D
Platte, R
Ellis, SD
Fineberg, E
Evans, DG
Lalloo, F
Eeles, R
Jacobs, C
Adlard, J
Davidson, R
Eccles, D
Cole, T
Cook, J
Godwin, A
Bove, B
Stoppa-Lyonnet, D
Caux-Moncoutier, V
Belotti, M
Tirapo, C
Mazoyer, S
Barjhoux, L
Boutry-Kryza, N
Pujol, P
Coupier, I
Peyrat, JP
Vennin, P
Muller, D
Fricker, JP
Venat-Bouvet, L
Johannsson, O
Isaacs, C
Schmutzler, R
Wappenschmidt, B
Meindl, A
Arnold, N
Varon-Mateeva, R
Niederacher, D
Sutter, C
Deissler, H
Preisler-Adams, S
Simard, J
Soucy, P
Durocher, F
Chenevix-Trench, G
Beesley, J
Chen, X
Rebbeck, T
Couch, F
Wang, X
Lindor, N
Fredericksen, Z
Pankratz, VS
Peterlongo, P
Bonanni, B
Fortuzzi, S
Peissel, B
Szabo, C
Mai, PL
Loud, JT
Lubinski, J
Source :
Jakubowska , A , Rozkrut , D , Antoniou , A , Hamann , U , Scott , RJ , McGuffog , L , Healy , S , Sinilnikova , OM , Rennert , G , Lejbkowicz , F , Flugelman , A , Andrulis , IL , Glendon , G , Ozcelik , H , Thomassen , M , Paligo , M , Aretini , P , Kantala , J , Aroer , B , von Wachenfeldt , A , Liljegren , A , Loman , N , Herbst , K , Kristoffersson , U , Rosenquist , R , Karlsson , P , Stenmark-Askmalm , M , Melin , B , Nathanson , KL , Domchek , SM , Byrski , T , Huzarski , T , Gronwald , J , Menkiszak , J , Cybulski , C , Serrano , P , Osorio , A , Cajal , TR , Tsitlaidou , M , Benitez , J , Gilbert , M , Rookus , M , Aalfs , CM , Kluijt , I , Boessenkool-Pape , JL , Meijers-Heijboer , HEJ , Oosterwijk , JC , van Asperen , CJ , Blok , MJ , Nelen , MR , van den Ouweland , A , Seynaeve , C , van der Luijt , RB , Devilee , P , Easton , DF , Peock , S , Frost , D , Platte , R , Ellis , SD , Fineberg , E , Evans , DG , Lalloo , F , Eeles , R , Jacobs , C , Adlard , J , Davidson , R , Eccles , D , Cole , T , Cook , J , Godwin , A , Bove , B , Stoppa-Lyonnet , D , Caux-Moncoutier , V , Belotti , M , Tirapo , C , Mazoyer , S , Barjhoux , L , Boutry-Kryza , N , Pujol , P , Coupier , I , Peyrat , JP , Vennin , P , Muller , D , Fricker , JP , Venat-Bouvet , L , Johannsson , O , Isaacs , C , Schmutzler , R , Wappenschmidt , B , Meindl , A , Arnold , N , Varon-Mateeva , R , Niederacher , D , Sutter , C , Deissler , H , Preisler-Adams , S , Simard , J , Soucy , P , Durocher , F , Chenevix-Trench , G , Beesley , J , Chen , X , Rebbeck , T , Couch , F , Wang , X , Lindor , N , Fredericksen , Z , Pankratz , VS , Peterlongo , P , Bonanni , B , Fortuzzi , S , Peissel , B , Szabo , C , Mai , PL , Loud , JT & Lubinski , J 2012 , ' Association of PHB 1630 C > T and MTHFR 677 C > T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study ' , British Journal of Cancer , vol. 106 , no. 12 , pp. 2016-2024 .
Publication Year :
2012

Abstract

BACKGROUND: The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity. METHODS: To evaluate the potential role of genetic variants within PHB and MTHFR in breast and ovarian cancer risk, 4102 BRCA1 and 2093 BRCA2 mutation carriers, and 6211 BRCA1 and 2902 BRCA2 carriers from the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA) were genotyped for the PHB 1630 C>T (rs6917) polymorphism and the MTHFR 677 C>T (rs1801133) polymorphism, respectively. RESULTS: There was no evidence of association between the PHB 1630 C>T and MTHFR 677 C>T polymorphisms with either disease for BRCA1 or BRCA2 mutation carriers when breast and ovarian cancer associations were evaluated separately. Analysis that evaluated associations for breast and ovarian cancer simultaneously showed some evidence that BRCA1 mutation carriers who had the rare homozygote genotype (TT) of the PHB 1630 C>T polymorphism were at increased risk of both breast and ovarian cancer (HR 1 CONCLUSION: The PHB 1630TT genotype may modify breast and ovarian cancer risks in BRCA1 mutation carriers. This association need to be evaluated in larger series of BRCA1 mutation carriers. British Journal of Cancer (2012) 106, 2016-2024. doi:10.1038/bjc.2012.160 www.bjcancer.com Published online 15 May 2012 (C) 2012 Cancer Research UK

Details

Database :
OAIster
Journal :
Jakubowska , A , Rozkrut , D , Antoniou , A , Hamann , U , Scott , RJ , McGuffog , L , Healy , S , Sinilnikova , OM , Rennert , G , Lejbkowicz , F , Flugelman , A , Andrulis , IL , Glendon , G , Ozcelik , H , Thomassen , M , Paligo , M , Aretini , P , Kantala , J , Aroer , B , von Wachenfeldt , A , Liljegren , A , Loman , N , Herbst , K , Kristoffersson , U , Rosenquist , R , Karlsson , P , Stenmark-Askmalm , M , Melin , B , Nathanson , KL , Domchek , SM , Byrski , T , Huzarski , T , Gronwald , J , Menkiszak , J , Cybulski , C , Serrano , P , Osorio , A , Cajal , TR , Tsitlaidou , M , Benitez , J , Gilbert , M , Rookus , M , Aalfs , CM , Kluijt , I , Boessenkool-Pape , JL , Meijers-Heijboer , HEJ , Oosterwijk , JC , van Asperen , CJ , Blok , MJ , Nelen , MR , van den Ouweland , A , Seynaeve , C , van der Luijt , RB , Devilee , P , Easton , DF , Peock , S , Frost , D , Platte , R , Ellis , SD , Fineberg , E , Evans , DG , Lalloo , F , Eeles , R , Jacobs , C , Adlard , J , Davidson , R , Eccles , D , Cole , T , Cook , J , Godwin , A , Bove , B , Stoppa-Lyonnet , D , Caux-Moncoutier , V , Belotti , M , Tirapo , C , Mazoyer , S , Barjhoux , L , Boutry-Kryza , N , Pujol , P , Coupier , I , Peyrat , JP , Vennin , P , Muller , D , Fricker , JP , Venat-Bouvet , L , Johannsson , O , Isaacs , C , Schmutzler , R , Wappenschmidt , B , Meindl , A , Arnold , N , Varon-Mateeva , R , Niederacher , D , Sutter , C , Deissler , H , Preisler-Adams , S , Simard , J , Soucy , P , Durocher , F , Chenevix-Trench , G , Beesley , J , Chen , X , Rebbeck , T , Couch , F , Wang , X , Lindor , N , Fredericksen , Z , Pankratz , VS , Peterlongo , P , Bonanni , B , Fortuzzi , S , Peissel , B , Szabo , C , Mai , PL , Loud , JT & Lubinski , J 2012 , ' Association of PHB 1630 C > T and MTHFR 677 C > T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study ' , British Journal of Cancer , vol. 106 , no. 12 , pp. 2016-2024 .
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Publication Type :
Electronic Resource
Accession number :
edsoai.on1313616096
Document Type :
Electronic Resource