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Fluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI): a prospective, multicentre, comparative effectiveness study
Authors :
Wiegers, E Lingsma, H Huijben, J Cooper, D Citerio, G Frisvold, S Helbok, R Maas, A Menon, D Moore, E Stocchetti, N Dippel, D Steyerberg, E van der Jagt, M Brooker, J Bragge, P Rosenfeld, J Cooper, J Beer, R Schoechl, H Rusnák, M Schwendenwein, E Antoni, A De Keyser, V Menovsky, T Van Praag, D Van der Steen, G Parizel, P Vande Vyvere, T Depreitere, B Van Hecke, W Verheyden, J Misset, B Ledoux, D Laureys, S Ghuysen, A Maréchal, H Dulière, G Gao, G Jiang, J Kondziella, D Fabricius, M Schou, R Blaabjerg, M Rosenlund, C Piippo-Karjalainen, A Raj, R Pirinen, M Ripatti, S Palotie, A Ylén, P Posti, J Tenovuo, O Takala, R Payen, J Vega, E Lejeune, A Audibert, G Degos, V Benali, H Galanaud, D Perlbarg, V Puybasset, L Azouvi, P Legrand, V Dahyot-Fizelier, C Rossaint, R Coburn, M Kowark, A Clusmann, H Dreier, J Wolf, S Vajkoczy, P Maegele, M Gratz, J Schäfer, N Lefering, R Covic, A von Steinbüchel, N Schmidt, S Bullinger, M Younsi, A Unterberg, A Mattern, J Sakowitz, O Sanchez-Porras, R Perera, N Beauvais, R Sandor, J Czeiter, E Buki, A Ezer, E Vámos, Z Melegh, B Tamás, V Sorinola, A Kovács, N Nyirádi, J Amrein, K Barzó, P Gupta, D Levi, L Rosenthal, G Furmanov, A Martino, C Beretta, L Calvi, M Azzolini, M Calappi, E Zoerle, T Ortolano, F Carbonara, M Caccioppola, A Vargiolu, A Chieregato, A Chevallard, G Della Corte, F Grossi, F Rossi, S Persona, P Berardino, M Cavallo, S Rambadagalla, M Ziverte, A Giga, L Valeinis, E Vilcinis, R Tamosuitis, T Rocka, S Ragauskas, A van der Naalt, J Jacobs, B Bartels, R den Boogert, H Kompanje, E Timmers, M Foks, K Haitsma, I Volovici, V Haagsma, J Mikolic, A Velt, K Voormolen, D Nieboer, D Sewalt, C Gravesteijn, B Polinder, S Tibboel, D van Wijk, R van Dijck, J van Essen, T Peul, W Schoonman, G Jones, K Feigin, V Te Ao, B Theadom, A Helseth, E Roe, C Roise, O Andelic, N Andreassen, L Anke, A Vik, A Skandsen, T Ples, H Tudora, C Negru, A Vulekovic, P Đilvesi, Đ Karan, M Golubovic, J Rehorcíková, V Taylor, M Brazinova, A Majdan, M Sahuquillo, J Radoi, A Carbayo Lozano, G Pomposo, I Lagares, A Gomez, P Castaño-León, A Gagliardo, P Oresic, M Bellander, B Lanyon, L George, P Muraleedharan, V Nelson, D Ackerlund, C Koskinen, L Sundström, N Brorsson, C Belli, A Manara, A Thomas, M Czosnyka, M Smielewski, P Cabeleira, M Coles, J Richardson, S Zeiler, F Stamatakis, E Williams, G Ercole, A Dixit, A Newcombe, V Richter, S Mcfadyen, C Hutchinson, P Kolias, A Adams, H Correia, M Rhodes, J Stewart, W Mcmahon, C Rueckert, D Glocker, B Tolias, C Dawes, H Esser, P van Heugten, C Curry, N Stanworth, S Lecky, F Otesile, O Johnson, F Dark, P Jankowski, S Lightfoot, R Wilson, L Horton, L Stevens, R Rosand, J Manley, G Jarrett, M Brinck, V Wang, K Yang, Z Vespa, P Gruen, R Cameron, P Donoghue, E Gantner, D Murray, L Varma, D Trapani, T Vallance, S Macisaac, C Jordan, A Wiegers, Eveline Janine Anna Lingsma, Hester Floor Huijben, Jilske Antonia Cooper, David James Citerio, Giuseppe Frisvold, Shirin Helbok, Raimund Maas, Andrew Ian Ramsay Menon, David Krishna Moore, Elizabeth Madeleine Stocchetti, Nino Dippel, Diederik Willem Steyerberg, Ewout Willem van der Jagt, Mathieu Brooker, Joanne Bragge, Peter Rosenfeld, Jeffrey Cooper, Jamie D. Beer, Ronny Schoechl, Herbert Rusnák, Martin Schwendenwein, Elisabeth Antoni, Anna De Keyser, Véronique Menovsky, Tomas Van Praag, Dominique Maas, Andrew I. R. Van der Steen, Gregory Parizel, Paul M. Vande Vyvere, Thijs Depreitere, Bart Van Hecke, Wim Verheyden, Jan Misset, Benoit Ledoux, Didier Laureys, Steven Ghuysen, Alexandre Maréchal, Hugues Dulière, Guy-Loup Gao, Guoyi Jiang, Ji-yao Kondziella, Daniel Fabricius, Martin Schou, Rico Frederik Blaabjerg, Morten Rosenlund, Christina Piippo-Karjalainen, Anna Raj, Rahul Pirinen, Matti Ripatti, Samuli Palotie, Aarno Ylén, Peter Posti, Jussi P. Tenovuo, Olli Takala, Riikka Payen, Jean-François Vega, Emmanuel Lejeune, Aurelie Audibert, Gérard Degos, Vincent Benali, Habib Galanaud, Damien Perlbarg, Vincent Puybasset, Louis Azouvi, Philippe Legrand, Valerie Dahyot-Fizelier, Claire Rossaint, Rolf Coburn, Mark Steven Kowark, Ana Clusmann, Hans Dreier, Jens Wolf, Stefan Vajkoczy, Peter Maegele, Marc Gratz, Johannes Schäfer, Nadine Lefering, Rolf Covic, Amra von Steinbüchel, Nicole Schmidt, Silke Bullinger, Monika Younsi, Alexander Unterberg, Andreas Mattern, Julia Sakowitz, Oliver Sanchez-Porras, Renan Perera, Natascha Beauvais, Romuald Sandor, Janos Czeiter, Endre Buki, Andras Ezer, Erzsébet Vámos, Zoltán Melegh, Béla Tamás, Viktória Sorinola, Abayomi Kovács, Noémi Nyirádi, József Amrein, Krisztina Barzó, Pál Gupta, Deepak Levi, Leon Rosenthal, Guy Furmanov, Alex Martino, Costanza Beretta, Luigi Calvi, Maria Rosa Azzolini, Maria Luisa Calappi, Emiliana Zoerle, Tommaso Ortolano, Fabrizio Carbonara, Marco Caccioppola, Alessio Vargiolu, Alessia Chieregato, Arturo Chevallard, Giorgio Della Corte, Francesco Grossi, Francesca Rossi, Sandra Persona, Paolo Berardino, Maurizio Cavallo, Simona Rambadagalla, Malinka Ziverte, Agate Giga, Lelde Valeinis, Egils Vilcinis, Rimantas Tamosuitis, Tomas Rocka, Saulius Ragauskas, Arminas van der Naalt, Joukje Jacobs, Bram Steyerberg, Ewout W. Bartels, Ronald den Boogert, Hugo Kompanje, Erwin Timmers, Marjolijn Foks, Kelly Haitsma, Iain Volovici, Victor Haagsma, Juanita A. Mikolic, Ana Lingsma, Hester Velt, Kimberley Huijben, Jilske Voormolen, Daphne Nieboer, Daan Wiegers, Eveline Sewalt, Charlie Gravesteijn, Benjamin Polinder, Suzanne Tibboel, Dick van Wijk, Roel van Dijck, Jeroen T. J. M. van Essen, Thomas A. Peul, Wilco Schoonman, Guus Jones, Kelly Feigin, Valery L. Te Ao, Braden Theadom, Alice Helseth, Eirik Roe, Cecilie Roise, Olav Andelic, Nada Andreassen, Lasse Anke, Audny Vik, Anne Skandsen, Toril Ples, Horia Tudora, Cristina Maria Negru, Ancuta Vulekovic, Peter Đilvesi, Đula Karan, Mladen Golubovic, Jagoš Rehorcíková, Veronika Taylor, Mark Steven Brazinova, Alexandra Majdan, Marek Sahuquillo, Juan Radoi, Andreea Carbayo Lozano, Guillermo Pomposo, Inigo Lagares, Alfonso Gomez, Pedro A. Castaño-León, Ana M. Gagliardo, Pablo Oresic, Matej Bellander, Bo-Michael Lanyon, Linda George, Pradeep Muraleedharan, Visakh Nelson, David Ackerlund, Cecilia Koskinen, Lars-Owe Sundström, Nina Brorsson, Camilla Belli, Antonio Manara, Alex Thomas, Matt Czosnyka, Marek Smielewski, Peter Cabeleira, Manuel Coles, Jonathan Richardson, Sylvia Zeiler, Frederick A. Stamatakis, Emmanuel Williams, Guy Menon, David Ercole, Ari Dixit, Abhishek Newcombe, Virginia Richter, Sophie McFadyen, Charles Hutchinson, Peter J. Kolias, Angelos G. Adams, Hadie Correia, Marta Rhodes, Jonathan Stewart, William McMahon, Catherine Rueckert, Daniel Glocker, Ben Tolias, Christos Dawes, Helen Esser, Patrick van Heugten, Caroline Curry, Nicola Stanworth, Simon Lecky, Fiona Otesile, Olubukola Johnson, Faye Dark, Paul Jankowski, Stefan Lightfoot, Roger Wilson, Lindsay Horton, Lindsay Stevens, Robert Rosand, Jonathan Manley, Geoffrey Jarrett, Mike Brinck, Vibeke Wang, Kevin K. W. Yang, Zhihui Vespa, Paul M. Gruen, Russell L. Cameron, Peter Donoghue, Emma Gantner, Dashiell Gruen, Russel Murray, Lynette Rosenfeld, Jeffrey V. Varma, Dinesh Trapani, Tony Vallance, Shirley MacIsaac, Cristopher Jordan, Andrea Wiegers, E Lingsma, H Huijben, J Cooper, D Citerio, G Frisvold, S Helbok, R Maas, A Menon, D Moore, E Stocchetti, N Dippel, D Steyerberg, E van der Jagt, M Brooker, J Bragge, P Rosenfeld, J Cooper, J Beer, R Schoechl, H Rusnák, M Schwendenwein, E Antoni, A De Keyser, V Menovsky, T Van Praag, D Van der Steen, G Parizel, P Vande Vyvere, T Depreitere, B Van Hecke, W Verheyden, J Misset, B Ledoux, D Laureys, S Ghuysen, A Maréchal, H Dulière, G Gao, G Jiang, J Kondziella, D Fabricius, M Schou, R Blaabjerg, M Rosenlund, C Piippo-Karjalainen, A Raj, R Pirinen, M Ripatti, S Palotie, A Ylén, P Posti, J Tenovuo, O Takala, R Payen, J Vega, E Lejeune, A Audibert, G Degos, V Benali, H Galanaud, D Perlbarg, V Puybasset, L Azouvi, P Legrand, V Dahyot-Fizelier, C Rossaint, R Coburn, M Kowark, A Clusmann, H Dreier, J Wolf, S Vajkoczy, P Maegele, M Gratz, J Schäfer, N Lefering, R Covic, A von Steinbüchel, N Schmidt, S Bullinger, M Younsi, A Unterberg, A Mattern, J Sakowitz, O Sanchez-Porras, R Perera, N Beauvais, R Sandor, J Czeiter, E Buki, A Ezer, E Vámos, Z Melegh, B Tamás, V Sorinola, A Kovács, N Nyirádi, J Amrein, K Barzó, P Gupta, D Levi, L Rosenthal, G Furmanov, A Martino, C Beretta, L Calvi, M Azzolini, M Calappi, E Zoerle, T Ortolano, F Carbonara, M Caccioppola, A Vargiolu, A Chieregato, A Chevallard, G Della Corte, F Grossi, F Rossi, S Persona, P Berardino, M Cavallo, S Rambadagalla, M Ziverte, A Giga, L Valeinis, E Vilcinis, R Tamosuitis, T Rocka, S Ragauskas, A van der Naalt, J Jacobs, B Bartels, R den Boogert, H Kompanje, E Timmers, M Foks, K Haitsma, I Volovici, V Haagsma, J Mikolic, A Velt, K Voormolen, D Nieboer, D Sewalt, C Gravesteijn, B Polinder, S Tibboel, D van Wijk, R van Dijck, J van Essen, T Peul, W Schoonman, G Jones, K Feigin, V Te Ao, B Theadom, A Helseth, E Roe, C Roise, O Andelic, N Andreassen, L Anke, A Vik, A Skandsen, T Ples, H Tudora, C Negru, A Vulekovic, P Đilvesi, Đ Karan, M Golubovic, J Rehorcíková, V Taylor, M Brazinova, A Majdan, M Sahuquillo, J Radoi, A Carbayo Lozano, G Pomposo, I Lagares, A Gomez, P Castaño-León, A Gagliardo, P Oresic, M Bellander, B Lanyon, L George, P Muraleedharan, V Nelson, D Ackerlund, C Koskinen, L Sundström, N Brorsson, C Belli, A Manara, A Thomas, M Czosnyka, M Smielewski, P Cabeleira, M Coles, J Richardson, S Zeiler, F Stamatakis, E Williams, G Ercole, A Dixit, A Newcombe, V Richter, S Mcfadyen, C Hutchinson, P Kolias, A Adams, H Correia, M Rhodes, J Stewart, W Mcmahon, C Rueckert, D Glocker, B Tolias, C Dawes, H Esser, P van Heugten, C Curry, N Stanworth, S Lecky, F Otesile, O Johnson, F Dark, P Jankowski, S Lightfoot, R Wilson, L Horton, L Stevens, R Rosand, J Manley, G Jarrett, M Brinck, V Wang, K Yang, Z Vespa, P Gruen, R Cameron, P Donoghue, E Gantner, D Murray, L Varma, D Trapani, T Vallance, S Macisaac, C Jordan, A Wiegers, Eveline Janine Anna Lingsma, Hester Floor Huijben, Jilske Antonia Cooper, David James Citerio, Giuseppe Frisvold, Shirin Helbok, Raimund Maas, Andrew Ian Ramsay Menon, David Krishna Moore, Elizabeth Madeleine Stocchetti, Nino Dippel, Diederik Willem Steyerberg, Ewout Willem van der Jagt, Mathieu Brooker, Joanne Bragge, Peter Rosenfeld, Jeffrey Cooper, Jamie D. Beer, Ronny Schoechl, Herbert Rusnák, Martin Schwendenwein, Elisabeth Antoni, Anna De Keyser, Véronique Menovsky, Tomas Van Praag, Dominique Maas, Andrew I. R. Van der Steen, Gregory Parizel, Paul M. Vande Vyvere, Thijs Depreitere, Bart Van Hecke, Wim Verheyden, Jan Misset, Benoit Ledoux, Didier Laureys, Steven Ghuysen, Alexandre Maréchal, Hugues Dulière, Guy-Loup Gao, Guoyi Jiang, Ji-yao Kondziella, Daniel Fabricius, Martin Schou, Rico Frederik Blaabjerg, Morten Rosenlund, Christina Piippo-Karjalainen, Anna Raj, Rahul Pirinen, Matti Ripatti, Samuli Palotie, Aarno Ylén, Peter Posti, Jussi P. Tenovuo, Olli Takala, Riikka Payen, Jean-François Vega, Emmanuel Lejeune, Aurelie Audibert, Gérard Degos, Vincent Benali, Habib Galanaud, Damien Perlbarg, Vincent Puybasset, Louis Azouvi, Philippe Legrand, Valerie Dahyot-Fizelier, Claire Rossaint, Rolf Coburn, Mark Steven Kowark, Ana Clusmann, Hans Dreier, Jens Wolf, Stefan Vajkoczy, Peter Maegele, Marc Gratz, Johannes Schäfer, Nadine Lefering, Rolf Covic, Amra von Steinbüchel, Nicole Schmidt, Silke Bullinger, Monika Younsi, Alexander Unterberg, Andreas Mattern, Julia Sakowitz, Oliver Sanchez-Porras, Renan Perera, Natascha Beauvais, Romuald Sandor, Janos Czeiter, Endre Buki, Andras Ezer, Erzsébet Vámos, Zoltán Melegh, Béla Tamás, Viktória Sorinola, Abayomi Kovács, Noémi Nyirádi, József Amrein, Krisztina Barzó, Pál Gupta, Deepak Levi, Leon Rosenthal, Guy Furmanov, Alex Martino, Costanza Beretta, Luigi Calvi, Maria Rosa Azzolini, Maria Luisa Calappi, Emiliana Zoerle, Tommaso Ortolano, Fabrizio Carbonara, Marco Caccioppola, Alessio Vargiolu, Alessia Chieregato, Arturo Chevallard, Giorgio Della Corte, Francesco Grossi, Francesca Rossi, Sandra Persona, Paolo Berardino, Maurizio Cavallo, Simona Rambadagalla, Malinka Ziverte, Agate Giga, Lelde Valeinis, Egils Vilcinis, Rimantas Tamosuitis, Tomas Rocka, Saulius Ragauskas, Arminas van der Naalt, Joukje Jacobs, Bram Steyerberg, Ewout W. Bartels, Ronald den Boogert, Hugo Kompanje, Erwin Timmers, Marjolijn Foks, Kelly Haitsma, Iain Volovici, Victor Haagsma, Juanita A. Mikolic, Ana Lingsma, Hester Velt, Kimberley Huijben, Jilske Voormolen, Daphne Nieboer, Daan Wiegers, Eveline Sewalt, Charlie Gravesteijn, Benjamin Polinder, Suzanne Tibboel, Dick van Wijk, Roel van Dijck, Jeroen T. J. M. van Essen, Thomas A. Peul, Wilco Schoonman, Guus Jones, Kelly Feigin, Valery L. Te Ao, Braden Theadom, Alice Helseth, Eirik Roe, Cecilie Roise, Olav Andelic, Nada Andreassen, Lasse Anke, Audny Vik, Anne Skandsen, Toril Ples, Horia Tudora, Cristina Maria Negru, Ancuta Vulekovic, Peter Đilvesi, Đula Karan, Mladen Golubovic, Jagoš Rehorcíková, Veronika Taylor, Mark Steven Brazinova, Alexandra Majdan, Marek Sahuquillo, Juan Radoi, Andreea Carbayo Lozano, Guillermo Pomposo, Inigo Lagares, Alfonso Gomez, Pedro A. Castaño-León, Ana M. Gagliardo, Pablo Oresic, Matej Bellander, Bo-Michael Lanyon, Linda George, Pradeep Muraleedharan, Visakh Nelson, David Ackerlund, Cecilia Koskinen, Lars-Owe Sundström, Nina Brorsson, Camilla Belli, Antonio Manara, Alex Thomas, Matt Czosnyka, Marek Smielewski, Peter Cabeleira, Manuel Coles, Jonathan Richardson, Sylvia Zeiler, Frederick A. Stamatakis, Emmanuel Williams, Guy Menon, David Ercole, Ari Dixit, Abhishek Newcombe, Virginia Richter, Sophie McFadyen, Charles Hutchinson, Peter J. Kolias, Angelos G. Adams, Hadie Correia, Marta Rhodes, Jonathan Stewart, William McMahon, Catherine Rueckert, Daniel Glocker, Ben Tolias, Christos Dawes, Helen Esser, Patrick van Heugten, Caroline Curry, Nicola Stanworth, Simon Lecky, Fiona Otesile, Olubukola Johnson, Faye Dark, Paul Jankowski, Stefan Lightfoot, Roger Wilson, Lindsay Horton, Lindsay Stevens, Robert Rosand, Jonathan Manley, Geoffrey Jarrett, Mike Brinck, Vibeke Wang, Kevin K. W. Yang, Zhihui Vespa, Paul M. Gruen, Russell L. Cameron, Peter Donoghue, Emma Gantner, Dashiell Gruen, Russel Murray, Lynette Rosenfeld, Jeffrey V. Varma, Dinesh Trapani, Tony Vallance, Shirley MacIsaac, Cristopher Jordan, Andrea
Publication Year :
2021
Abstract
Background: Fluid therapy—the administration of fluids to maintain adequate organ tissue perfusion and oxygenation—is essential in patients admitted to the intensive care unit (ICU) with traumatic brain injury. We aimed to quantify the variability in fluid management policies in patients with traumatic brain injury and to study the effect of this variability on patients' outcomes. Methods: We did a prospective, multicentre, comparative effectiveness study of two observational cohorts: CENTER-TBI in Europe and OzENTER-TBI in Australia. Patients from 55 hospitals in 18 countries, aged 16 years or older with traumatic brain injury requiring a head CT, and admitted to the ICU were included in this analysis. We extracted data on demographics, injury, and clinical and treatment characteristics, and calculated the mean daily fluid balance (difference between fluid input and loss) and mean daily fluid input during ICU stay per patient. We analysed the association of fluid balance and input with ICU mortality and functional outcome at 6 months, measured by the Glasgow Outcome Scale Extended (GOSE). Patient-level analyses relied on adjustment for key characteristics per patient, whereas centre-level analyses used the centre as the instrumental variable. Findings: 2125 patients enrolled in CENTER-TBI and OzENTER-TBI between Dec 19, 2014, and Dec 17, 2017, were eligible for inclusion in this analysis. The median age was 50 years (IQR 31 to 66) and 1566 (74%) of patients were male. The median of the mean daily fluid input ranged from 1·48 L (IQR 1·12 to 2·09) to 4·23 L (3·78 to 4·94) across centres. The median of the mean daily fluid balance ranged from −0·85 L (IQR −1·51 to −0·49) to 1·13 L (0·99 to 1·37) across centres. In patient-level analyses, a mean positive daily fluid balance was associated with higher ICU mortality (odds ratio [OR] 1·10 [95% CI 1·07 to 1·12] per 0·1 L increase) and worse functional outcome (1·04 [1·02 to 1·05] per 0·1 L increase); higher mean daily flui
Details
Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1308940046
Document Type :
Electronic Resource