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Aspiration Risk Factors, Microbiology, and Empiric Antibiotics for Patients Hospitalized With Community-Acquired Pneumonia
Authors :
Marin-Corral, J Pascual-Guardia, S Amati, F Aliberti, S Masclans, J Soni, N Rodriguez, A Sibila, O Sanz, F Sotgiu, G Anzueto, A Dimakou, K Petrino, R van de Garde, E Restrepo, M Aruj, P Attorri, S Barimboim, E Caeiro, J Garzon, M Cambursano, V Adrian Ceccato, V Chertcoff, J Lascar, F Di Tulio, F Diaz, A de Vedia, L Ganaha, M Lambert, S Lopardo, G Luna, C Malberti, A Morcillo, N Tartara, S Pensotti, C Pereyra, B Scapellato, P Stagnaro, J Shah, S Lotsch, F Thalhammer, F Anseeuw, K Francois, C Van Braeckel, E Vincent, J Djimon, M Bashi, J Dodo, R Nouer, S Chipev, P Encheva, M Miteva, D Petkova, D Balkissou, A Pefura Yone, E Mbatchou Ngahane, B Shen, N Xu, J Bustamante Rico, C Buitrago, R Pereira Paternina, F Kayembe Ntumba, J Carevic, V Jakopovic, M Jankovic, M Matkovic, Z Mitrecic, I Bouchy Jacobsson, M Christensen, A Heitmann Bodtger, U Meyer, C Jensen, A Baunbaek-knudsen, G Petersen, P Andersen, S El-Said Abd El-Wahhab, I Morsy, N Shafiek, H Sobh, E Abdulsemed, K Bertrand, F Brun-Buisson, C de Montmollin, E Fartoukh, M Messika, J Tattevin, P Khoury, A Ebruke, B Dreher, M Kolditz, M Meisinger, M Pletz, M Hagel, S Rupp, J Schaberg, T Spielmanns, M Creutz, P Suttorp, N Siaw-Lartey, B Papapetrou, D Tsigou, E Ampazis, D Kaimakamis, E Bhatia, M Dhar, R D'Souza, G Garg, R Koul, P Mahesh, P Jayaraj, B Narayan, K Udnur, H Krishnamurthy, S Kant, S Swarnakar, R Limaye, S Salvi, S Golshani, K Keatings, V Martin-Loeches, I Maor, Y Strahilevitz, J Faverio, P Battaglia, S Carrabba, M Ceriana, P Confalonieri, M Monforte, A Del Prato, B De Rosa, M Fantini, R Fiorentino, G Gammino, M Menzella, F Milani, G Nava, S Palmiero, G Gabrielli, B Rossi, P Sorino, C Steinhilber, G Zanforlin, A San Luca, O Franzetti, F Carugati, M Morosi, M Monge, E Carone, M Patella, V Scarlata, S Comel, A Kurahashi, K Bacha, Z Ugalde, D Zuniga, O Villegas, J Medenica, M Mihsra, D Shrestha, P Ridgeon, E Awokola, B Adefuye Bolanle Olufunlola, O Olumide, S Ukwaja, K Irfan, M Minarowski, L Szymon, S Froes, F Leuschner, P Meireles, M Ferrao, C Neves, J Abel, S Ravara, S Brocovschii, V Rusu, D Toma, C Chirita, D Dorobat, C Birkun, A Kaluzhenina, A Almotairi, A Ali Bukhary, Z Edathodu, J Fathy, A Abdulaziz Enani, A Mohamed, N Memon, J Bella, A Bogdanovic, S Milenkovic, B Pesut, D Borderias, L Bordon Garcia, N Alarcon, H Cilloniz, C Torres, A Diaz-Brito, V Casas, X Gonzalez, A Fernandez-Almira, M Interna, M Gallego, M Gaspar-GarcIa, I Gonzalez del Castillo, J Victoria, P Martinez, E Malo de Molina, R Marcos, P Menendez, R Pando-Sandoval, A Aymerich, C Lacoma de la Torre, A Garcia-Olive, I Rello, J Moyano, S Rodrigo-Troyano, A Sole-Violan, J Uranga, A van Boven, J Torra, E Pujol, J Feldman, C Yum, H Arnauld Attannon Fiogbe, I Yangui, F Bilaceroglu, S Levent Dalar, I Yilmaz, U Bogomolov, A Elahi, N Dhasmana, D Feneley, A Hill, A Rudran, B Ruiz-Buitrago, S Campbell, M Whitaker, P Youzguin, A Singanayagam, A Hancock, C Villafuerte, D Allen, K Brito, V Dietz, J Dysart, C Kellie, S Ricardo, A Meier, G Gaga, M Holland, T Bergin, S Kheir, F Landmeier, M Lois, M Nair, G Patel, H Reyes, K Rodriguez-Cintron, W Saito, S Noda, J Hinojosa, C Levine, S Reyes, L Angel, L Whitlow, K Hipskind, J Sukhija, K Totten, V Wunderink, R Shah, R Mateyo, K Noriega, L Alvarado, E Aman, M Labra, L Marin-Corral J. Pascual-Guardia S. Amati F. Aliberti S. Masclans J. R. Soni N. Rodriguez A. Sibila O. Sanz F. Sotgiu G. Anzueto A. Dimakou K. Petrino R. van de Garde E. Restrepo M. I. Aruj P. K. Attorri S. Barimboim E. Caeiro J. P. Garzon M. I. Cambursano V. H. Adrian Ceccato V. H. D. C. A. Chertcoff J. Lascar F. Di Tulio F. Diaz A. C. de Vedia L. Ganaha M. C. Lambert S. Lopardo G. Luna C. M. Malberti A. G. Morcillo N. Tartara S. Pensotti C. Pereyra B. Scapellato P. G. Stagnaro J. P. Shah S. Lotsch F. Thalhammer F. Anseeuw K. Francois C. A. Van Braeckel E. Vincent J. L. Djimon M. Z. Bashi J. Dodo R. Nouer S. A. Chipev P. Encheva M. Miteva D. Petkova D. Balkissou A. D. Pefura Yone E. W. Mbatchou Ngahane B. H. Shen N. Xu J. -F. Bustamante Rico C. A. Buitrago R. Pereira Paternina F. J. Kayembe Ntumba J. -M. Carevic V. V. Jakopovic M. Jankovic M. Matkovic Z. Mitrecic I. Bouchy Jacobsson M. -L. Christensen A. B. Heitmann Bodtger U. C. Meyer C. N. Jensen A. V. Baunbaek-knudsen G. Petersen P. T. Andersen S. El-Said Abd El-Wahhab I. Morsy N. E. Shafiek H. Sobh E. Abdulsemed K. A. Bertrand F. Brun-Buisson C. de Montmollin E. Fartoukh M. Messika J. Tattevin P. Khoury A. Ebruke B. Dreher M. Kolditz M. Meisinger M. Pletz M. W. Hagel S. Rupp J. Schaberg T. Spielmanns M. Creutz P. Suttorp N. Siaw-Lartey B. Papapetrou D. Tsigou E. Ampazis D. Kaimakamis E. Bhatia M. Dhar R. D'Souza G. Garg R. Koul P. A. Mahesh P. A. Jayaraj B. S. Narayan K. V. Udnur H. B. Krishnamurthy S. B. Kant S. Swarnakar R. Limaye S. Salvi S. Golshani K. Keatings V. M. Martin-Loeches I. Maor Y. Strahilevitz J. Faverio P. Battaglia S. Carrabba M. Ceriana P. Confalonieri M. Monforte A. D. Del Prato B. De Rosa M. Fantini R. Fiorentino G. Gammino M. A. Menzella F. Milani G. Nava S. Palmiero G. Gabrielli B. Rossi P. Sorino C. Steinhilber G. Zanforlin A. San Luca O. Franzetti F. Carugati M. Morosi M. Monge E. Carone M. Patella V. Scarlata S. Comel A. Kurahashi K. Bacha Z. A. Ugalde D. B. Zuniga O. C. Villegas J. F. Medenica M. Mihsra D. R. Shrestha P. Ridgeon E. Awokola B. I. Adefuye Bolanle Olufunlola O. N. O. Olumide S. Ukwaja K. N. Irfan M. Minarowski L. Szymon S. Froes F. Leuschner P. Meireles M. Ferrao C. Neves J. Abel Salazar Ravara S. B. Brocovschii V. Rusu D. Toma C. Chirita D. Dorobat C. M. Birkun A. Kaluzhenina A. Almotairi A. Ali Bukhary Z. A. Edathodu J. Fathy A. Abdulaziz Enani A. M. Mohamed N. E. Memon J. U. Bella A. Bogdanovic S. N. Milenkovic B. Pesut D. Borderias L. Bordon Garcia N. M. Alarcon H. C. Cilloniz C. Torres A. Diaz-Brito V. Casas X. Gonzalez A. E. Fernandez-Almira M. L. Interna M. Gallego M. Gaspar-GarcIa I. Gonzalez del Castillo J. Victoria P. J. Martinez E. L. Malo de Molina R. Marcos P. J. Menendez R. Pando-Sandoval A. Aymerich C. P. Lacoma de la Torre A. Garcia-Olive I. Rello J. Moyano S. Rodrigo-Troyano A. Sole-Violan J. Uranga A. van Boven J. F. Torra E. V. Pujol J. A. Feldman C. Yum H. K. Arnauld Attannon Fiogbe I. U. Yangui F. Bilaceroglu S. Levent Dalar I. D. Yilmaz U. Bogomolov A. Elahi N. Dhasmana D. J. Feneley A. Hill A. T. Rudran B. Ruiz-Buitrago S. Campbell M. Whitaker P. Youzguin A. Singanayagam A. Hancock C. Villafuerte D. Allen K. S. Brito V. Dietz J. Dysart C. E. Kellie S. M. Ricardo A. Franco-Sadud C. J. Meier G. Gaga M. Holland T. L. Bergin S. P. Kheir F. Landmeier M. Lois M. Nair G. B. Patel H. Reyes K. Rodriguez-Cintron W. Saito S. Noda J. Hinojosa C. I. Levine S. M. Reyes L. F. Angel L. F. Whitlow K. S. Hipskind J. Sukhija K. Totten V. Wunderink R. G. Shah R. D. Mateyo K. J. Noriega L. Alvarado E. Aman M. Labra L. Marin-Corral, J Pascual-Guardia, S Amati, F Aliberti, S Masclans, J Soni, N Rodriguez, A Sibila, O Sanz, F Sotgiu, G Anzueto, A Dimakou, K Petrino, R van de Garde, E Restrepo, M Aruj, P Attorri, S Barimboim, E Caeiro, J Garzon, M Cambursano, V Adrian Ceccato, V Chertcoff, J Lascar, F Di Tulio, F Diaz, A de Vedia, L Ganaha, M Lambert, S Lopardo, G Luna, C Malberti, A Morcillo, N Tartara, S Pensotti, C Pereyra, B Scapellato, P Stagnaro, J Shah, S Lotsch, F Thalhammer, F Anseeuw, K Francois, C Van Braeckel, E Vincent, J Djimon, M Bashi, J Dodo, R Nouer, S Chipev, P Encheva, M Miteva, D Petkova, D Balkissou, A Pefura Yone, E Mbatchou Ngahane, B Shen, N Xu, J Bustamante Rico, C Buitrago, R Pereira Paternina, F Kayembe Ntumba, J Carevic, V Jakopovic, M Jankovic, M Matkovic, Z Mitrecic, I Bouchy Jacobsson, M Christensen, A Heitmann Bodtger, U Meyer, C Jensen, A Baunbaek-knudsen, G Petersen, P Andersen, S El-Said Abd El-Wahhab, I Morsy, N Shafiek, H Sobh, E Abdulsemed, K Bertrand, F Brun-Buisson, C de Montmollin, E Fartoukh, M Messika, J Tattevin, P Khoury, A Ebruke, B Dreher, M Kolditz, M Meisinger, M Pletz, M Hagel, S Rupp, J Schaberg, T Spielmanns, M Creutz, P Suttorp, N Siaw-Lartey, B Papapetrou, D Tsigou, E Ampazis, D Kaimakamis, E Bhatia, M Dhar, R D'Souza, G Garg, R Koul, P Mahesh, P Jayaraj, B Narayan, K Udnur, H Krishnamurthy, S Kant, S Swarnakar, R Limaye, S Salvi, S Golshani, K Keatings, V Martin-Loeches, I Maor, Y Strahilevitz, J Faverio, P Battaglia, S Carrabba, M Ceriana, P Confalonieri, M Monforte, A Del Prato, B De Rosa, M Fantini, R Fiorentino, G Gammino, M Menzella, F Milani, G Nava, S Palmiero, G Gabrielli, B Rossi, P Sorino, C Steinhilber, G Zanforlin, A San Luca, O Franzetti, F Carugati, M Morosi, M Monge, E Carone, M Patella, V Scarlata, S Comel, A Kurahashi, K Bacha, Z Ugalde, D Zuniga, O Villegas, J Medenica, M Mihsra, D Shrestha, P Ridgeon, E Awokola, B Adefuye Bolanle Olufunlola, O Olumide, S Ukwaja, K Irfan, M Minarowski, L Szymon, S Froes, F Leuschner, P Meireles, M Ferrao, C Neves, J Abel, S Ravara, S Brocovschii, V Rusu, D Toma, C Chirita, D Dorobat, C Birkun, A Kaluzhenina, A Almotairi, A Ali Bukhary, Z Edathodu, J Fathy, A Abdulaziz Enani, A Mohamed, N Memon, J Bella, A Bogdanovic, S Milenkovic, B Pesut, D Borderias, L Bordon Garcia, N Alarcon, H Cilloniz, C Torres, A Diaz-Brito, V Casas, X Gonzalez, A Fernandez-Almira, M Interna, M Gallego, M Gaspar-GarcIa, I Gonzalez del Castillo, J Victoria, P Martinez, E Malo de Molina, R Marcos, P Menendez, R Pando-Sandoval, A Aymerich, C Lacoma de la Torre, A Garcia-Olive, I Rello, J Moyano, S Rodrigo-Troyano, A Sole-Violan, J Uranga, A van Boven, J Torra, E Pujol, J Feldman, C Yum, H Arnauld Attannon Fiogbe, I Yangui, F Bilaceroglu, S Levent Dalar, I Yilmaz, U Bogomolov, A Elahi, N Dhasmana, D Feneley, A Hill, A Rudran, B Ruiz-Buitrago, S Campbell, M Whitaker, P Youzguin, A Singanayagam, A Hancock, C Villafuerte, D Allen, K Brito, V Dietz, J Dysart, C Kellie, S Ricardo, A Meier, G Gaga, M Holland, T Bergin, S Kheir, F Landmeier, M Lois, M Nair, G Patel, H Reyes, K Rodriguez-Cintron, W Saito, S Noda, J Hinojosa, C Levine, S Reyes, L Angel, L Whitlow, K Hipskind, J Sukhija, K Totten, V Wunderink, R Shah, R Mateyo, K Noriega, L Alvarado, E Aman, M Labra, L Marin-Corral J. Pascual-Guardia S. Amati F. Aliberti S. Masclans J. R. Soni N. Rodriguez A. Sibila O. Sanz F. Sotgiu G. Anzueto A. Dimakou K. Petrino R. van de Garde E. Restrepo M. I. Aruj P. K. Attorri S. Barimboim E. Caeiro J. P. Garzon M. I. Cambursano V. H. Adrian Ceccato V. H. D. C. A. Chertcoff J. Lascar F. Di Tulio F. Diaz A. C. de Vedia L. Ganaha M. C. Lambert S. Lopardo G. Luna C. M. Malberti A. G. Morcillo N. Tartara S. Pensotti C. Pereyra B. Scapellato P. G. Stagnaro J. P. Shah S. Lotsch F. Thalhammer F. Anseeuw K. Francois C. A. Van Braeckel E. Vincent J. L. Djimon M. Z. Bashi J. Dodo R. Nouer S. A. Chipev P. Encheva M. Miteva D. Petkova D. Balkissou A. D. Pefura Yone E. W. Mbatchou Ngahane B. H. Shen N. Xu J. -F. Bustamante Rico C. A. Buitrago R. Pereira Paternina F. J. Kayembe Ntumba J. -M. Carevic V. V. Jakopovic M. Jankovic M. Matkovic Z. Mitrecic I. Bouchy Jacobsson M. -L. Christensen A. B. Heitmann Bodtger U. C. Meyer C. N. Jensen A. V. Baunbaek-knudsen G. Petersen P. T. Andersen S. El-Said Abd El-Wahhab I. Morsy N. E. Shafiek H. Sobh E. Abdulsemed K. A. Bertrand F. Brun-Buisson C. de Montmollin E. Fartoukh M. Messika J. Tattevin P. Khoury A. Ebruke B. Dreher M. Kolditz M. Meisinger M. Pletz M. W. Hagel S. Rupp J. Schaberg T. Spielmanns M. Creutz P. Suttorp N. Siaw-Lartey B. Papapetrou D. Tsigou E. Ampazis D. Kaimakamis E. Bhatia M. Dhar R. D'Souza G. Garg R. Koul P. A. Mahesh P. A. Jayaraj B. S. Narayan K. V. Udnur H. B. Krishnamurthy S. B. Kant S. Swarnakar R. Limaye S. Salvi S. Golshani K. Keatings V. M. Martin-Loeches I. Maor Y. Strahilevitz J. Faverio P. Battaglia S. Carrabba M. Ceriana P. Confalonieri M. Monforte A. D. Del Prato B. De Rosa M. Fantini R. Fiorentino G. Gammino M. A. Menzella F. Milani G. Nava S. Palmiero G. Gabrielli B. Rossi P. Sorino C. Steinhilber G. Zanforlin A. San Luca O. Franzetti F. Carugati M. Morosi M. Monge E. Carone M. Patella V. Scarlata S. Comel A. Kurahashi K. Bacha Z. A. Ugalde D. B. Zuniga O. C. Villegas J. F. Medenica M. Mihsra D. R. Shrestha P. Ridgeon E. Awokola B. I. Adefuye Bolanle Olufunlola O. N. O. Olumide S. Ukwaja K. N. Irfan M. Minarowski L. Szymon S. Froes F. Leuschner P. Meireles M. Ferrao C. Neves J. Abel Salazar Ravara S. B. Brocovschii V. Rusu D. Toma C. Chirita D. Dorobat C. M. Birkun A. Kaluzhenina A. Almotairi A. Ali Bukhary Z. A. Edathodu J. Fathy A. Abdulaziz Enani A. M. Mohamed N. E. Memon J. U. Bella A. Bogdanovic S. N. Milenkovic B. Pesut D. Borderias L. Bordon Garcia N. M. Alarcon H. C. Cilloniz C. Torres A. Diaz-Brito V. Casas X. Gonzalez A. E. Fernandez-Almira M. L. Interna M. Gallego M. Gaspar-GarcIa I. Gonzalez del Castillo J. Victoria P. J. Martinez E. L. Malo de Molina R. Marcos P. J. Menendez R. Pando-Sandoval A. Aymerich C. P. Lacoma de la Torre A. Garcia-Olive I. Rello J. Moyano S. Rodrigo-Troyano A. Sole-Violan J. Uranga A. van Boven J. F. Torra E. V. Pujol J. A. Feldman C. Yum H. K. Arnauld Attannon Fiogbe I. U. Yangui F. Bilaceroglu S. Levent Dalar I. D. Yilmaz U. Bogomolov A. Elahi N. Dhasmana D. J. Feneley A. Hill A. T. Rudran B. Ruiz-Buitrago S. Campbell M. Whitaker P. Youzguin A. Singanayagam A. Hancock C. Villafuerte D. Allen K. S. Brito V. Dietz J. Dysart C. E. Kellie S. M. Ricardo A. Franco-Sadud C. J. Meier G. Gaga M. Holland T. L. Bergin S. P. Kheir F. Landmeier M. Lois M. Nair G. B. Patel H. Reyes K. Rodriguez-Cintron W. Saito S. Noda J. Hinojosa C. I. Levine S. M. Reyes L. F. Angel L. F. Whitlow K. S. Hipskind J. Sukhija K. Totten V. Wunderink R. G. Shah R. D. Mateyo K. J. Noriega L. Alvarado E. Aman M. Labra L.
Publication Year :
2021
Abstract
Background: Aspiration community-acquired pneumonia (ACAP) and community-acquired pneumonia (CAP) in patients with aspiration risk factors (AspRFs) are infections associated with anaerobes, but limited evidence suggests their pathogenic role. Research Question: What are the aspiration risk factors, microbiology patterns, and empiric anti-anaerobic use in patients hospitalized with CAP? Study Design and Methods: This is a secondary analysis of GLIMP, an international, multicenter, point-prevalence study of adults hospitalized with CAP. Patients were stratified into three groups: (1) ACAP, (2) CAP/AspRF+ (CAP with AspRF), and (3) CAP/AspRF- (CAP without AspRF). Data on demographics, comorbidities, microbiological results, and anti-anaerobic antibiotics were analyzed in all groups. Patients were further stratified in severe and nonsevere CAP groups. Results: We enrolled 2,606 patients with CAP, of which 193 (7.4%) had ACAP. Risk factors independently associated with ACAP were male, bedridden, underweight, a nursing home resident, and having a history of stroke, dementia, mental illness, and enteral tube feeding. Among non-ACAP patients, 1,709 (70.8%) had CAP/AspRF+ and 704 (29.2%) had CAP/AspRF-. Microbiology patterns including anaerobes were similar between CAP/AspRF-, CAP/AspRF+ and ACAP (0.0% vs 1.03% vs 1.64%). Patients with severe ACAP had higher rates of total gram-negative bacteria (64.3% vs 44.3% vs 33.3%, P =.021) and lower rates of total gram-positive bacteria (7.1% vs 38.1% vs 50.0%, P <.001) when compared with patients with severe CAP/AspRF+ and severe CAP/AspRF-, respectively. Most patients (>50% in all groups) independent of AspRFs or ACAP received specific or broad-spectrum anti-anaerobic coverage antibiotics. Interpretation: Hospitalized patients with ACAP or CAP/AspRF+ had similar anaerobic flora compared with patients without aspiration risk factors. Gram-negative bacteria were more prevalent in patients with severe ACAP. Despite having similar
Details
Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1308938036
Document Type :
Electronic Resource