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A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin
- Publication Year :
- 2021
-
Abstract
- In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2–DDX5 interaction is impaired in cells expressing the BRCA2 missense variant found in breast cancer patients.
Details
- Database :
- OAIster
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1306016231
- Document Type :
- Electronic Resource