Supervised and Self-Supervised Learning for Accelerated Medical Imaging

Medical imaging technologies are life-changing owing to their non-invasive approaches to early detection of diseases. X-ray Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are two routinely used imaging modalities. CT scans are typically performed in seconds yet can expose patients to X-ray ionizing radiation; MRI utilizing radiofrequency waves is free of ionizing radiation, yet, is notorious for its long scan times. Data undersampling is a common and practical approach to reducing ionizing radiation in CT and reducing scan times in MRI. While data undersampling eases the burden of data acquisition, it puts higher requirements on image reconstruction as the undersampling artifacts start to manifest. This dissertation exploits the emerging technique, deep learning, to tackle the problem of image reconstruction from undersampled data in both CT and MRI applications. This dissertation explores learned reconstruction in supervised and unsupervised settings. We first propose a fully supervised reconstruction method for sparse-view dedicated breast CT, leading to three times radiation dose reduction. Supervised learning typically requires a vast quantity of fully sampled data. To address this limitation, we propose a supervised reconstruction using accelerated reference as the training label for multiple MR parameter mapping applications. The accelerated references obtained from model based compressed sensing (CS) methods are slow yet accurate. By mapping to these accelerated references, the proposed learning method reduces the reconstruction times by several orders of magnitude in comparison to conventional CS methods, making them clinically relevant. Building off of these supervised learning methods, we propose a self-supervised learning framework that combines k-space view sharing techniques with image-space Noise2Noise denoising for highly accelerated radial MR parameter mapping. We show superior parameter accuracy than view sharing techniques and improv