Association Between Blood PLT and RBC Related Indices and Disease Activity in Patients with Rheumatoid Arthritis

Li Xue,1 Li Tao,1 Haifeng Sun,2 Yan Wang,1 Yanping Zhang,1 Na Lei,1 Zeshi Liu,1 Hua Zhang,1 Li Jin,1 Ting Zhang,1 Jing Zhang,1 Hao Meng,1 Fang Huang,1 Yan Geng,1 Ming Li3 1Department of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710004, People’s Republic of China; 2Third Department of Medical Oncology, Shaanxi Provincial Cancer Hospital Affiliated to Medical College of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of China; 3Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaCorrespondence: Yan GengDepartment of Clinical Laboratory, The Second Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi’an, People’s Republic of ChinaEmail gengyanjyk@126.comMing LiDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of ChinaEmail minglil@126.comBackground: Platelet (PLT) and red blood cell (RBC) have been demonstrated to play a critical role in inflammatory processes. This study aimed to evaluate the association of blood PLT and RBC related parameters with the disease activity in rheumatoid arthritis (RA) patients, and also to investigate the role of these indices in differentiating among RA patients with different disease activity.Methods: Clinical data from RA patients were retrospectively analyzed. RA patients were divided into inactive group and active group according to DAS28-CRP. The relationship between blood PLT and RBC counts-related indices and DAS28-CRP was detected by Spearman correlation. ROC curve was used to assess the diagnostic value of these indices in differentiating active RA from inactive RA.Results: Active RA patients exhibited higher level of PLT counts but significantly lower levels of RBC counts, hemoglobin (Hb), red blood cells-platelet ratio (RPR) and hemoglobin-platelet ratio (HPR) com