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High-dose glycine impairs the prepulse inhibition measure of sensorimotor gating in humans

Authors :
O'Neill, B V
Croft, R J
Mann, C
Dang, O
Leung, Su
Galloway, M P
Phan, K L
Nathan, P J
O'Neill, B V
Croft, R J
Mann, C
Dang, O
Leung, Su
Galloway, M P
Phan, K L
Nathan, P J
Source :
Faculty of Health and Behavioural Sciences - Papers (Archive)
Publication Year :
2011

Abstract

An impaired capacity to filter or ‘gate’ sensory information is a core deficit in cognitive function associated with schizophrenia. These deficits have been linked in part to N-methyl-D-aspartate (NMDA) receptor dysfunction. An association between high levels of glycine, a positive allosteric modulator of the NMDA receptor, and sensorimotor gating impairments (i.e. prepulse inhibition (PPI) deficit) have been reported in animal models of schizophrenia as well as patients with schizophrenia. This study examined the acute effects of modulating the glycine site of the NMDA receptor (with high-dose glycine) on sensory gating as measured by PPI.

Details

Database :
OAIster
Journal :
Faculty of Health and Behavioural Sciences - Papers (Archive)
Notes :
application/pdf
Publication Type :
Electronic Resource
Accession number :
edsoai.on1298572894
Document Type :
Electronic Resource