Back to Search
Start Over
Multiple risk factors for diabetes mellitus in patients with chronic pancreatitis:A multicentre study of 1117 cases
- Source :
- Olesen , S S , Poulsen , J L , Novovic , S , Nøjgaard , C , Kalaitzakis , E , Jensen , N M , Engjom , T , Tjora , E , Waage , A , Hauge , T , Haas , S L , Vujasinovic , M , Barauskas , G , Pukitis , A , Ozola-Zālīte , I , Okhlobystin , A , Parhiala , M , Laukkarinen , J & Drewes , A M 2020 , ' Multiple risk factors for diabetes mellitus in patients with chronic pancreatitis : A multicentre study of 1117 cases ' , United European Gastroenterology Journal , vol. 8 , no. 4 , pp. 453-461 .
- Publication Year :
- 2020
-
Abstract
- BACKGROUND: Diabetes mellitus is a common complication of chronic pancreatitis. It is traditionally considered to develop as a consequence of beta cell loss, but there might be additional factors. Recent studies have highlighted the importance of type 2 diabetes-related risk factors in this context and population-based studies show increased risk of diabetes following acute pancreatitis. The aim of this study was to explore multiple risk factors for diabetes in patients with chronic pancreatitis.METHODS: We conducted a multicentre, cross-sectional study of patients with definitive chronic pancreatitis according to the M-ANNHEIM criteria. We used multivariable logistic regression models to determine risk factors independently associated with diabetes.RESULTS: The study included 1117 patients of whom 457 (40.9 %) had diabetes. The mean age was 52.8 ± 14.2 years and 67% were men. On multivariate analysis, parameters indicative of beta cell loss (pancreatic calcification, exocrine insufficiency, pancreatic resection) were confirmed as independent risk factors for diabetes (all p ≤ 0.02). In addition, type 2 diabetes-related risk factors (dyslipidaemia and overweight/obesity) were associated with the presence of diabetes (all p ≤ 0.002). Patients with a history of pancreatic fluid collections (indicative of previous attacks of acute pancreatitis) had a marginally increased risk of diabetes (p = 0.07).CONCLUSION: In patients with chronic pancreatitis the presence of diabetes is associated with multiple risk factors including type 2 diabetes-related factors. Our observations attest to the understanding of this entity and may have implications for treatment.
Details
- Database :
- OAIster
- Journal :
- Olesen , S S , Poulsen , J L , Novovic , S , Nøjgaard , C , Kalaitzakis , E , Jensen , N M , Engjom , T , Tjora , E , Waage , A , Hauge , T , Haas , S L , Vujasinovic , M , Barauskas , G , Pukitis , A , Ozola-Zālīte , I , Okhlobystin , A , Parhiala , M , Laukkarinen , J & Drewes , A M 2020 , ' Multiple risk factors for diabetes mellitus in patients with chronic pancreatitis : A multicentre study of 1117 cases ' , United European Gastroenterology Journal , vol. 8 , no. 4 , pp. 453-461 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1296097677
- Document Type :
- Electronic Resource