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Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody
- Source :
- Macías-León , J , Bermejo , I A , Asín , A , García-García , A , Compañón , I , Jiménez-Moreno , E , Coelho , H , Mangini , V , Albuquerque , I S , Marcelo , F , Asensio , J L , Bernardes , G J L , Joshi , H J , Fiammengo , R , Blixt , O , Hurtado-Guerrero , R & Corzana , F 2020 , ' Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody ' , Chemical communications (Cambridge, England) , vol. 56 , no. 96 , pp. 15137-15140 .
- Publication Year :
- 2020
-
Abstract
- The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools.
Details
- Database :
- OAIster
- Journal :
- Macías-León , J , Bermejo , I A , Asín , A , García-García , A , Compañón , I , Jiménez-Moreno , E , Coelho , H , Mangini , V , Albuquerque , I S , Marcelo , F , Asensio , J L , Bernardes , G J L , Joshi , H J , Fiammengo , R , Blixt , O , Hurtado-Guerrero , R & Corzana , F 2020 , ' Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody ' , Chemical communications (Cambridge, England) , vol. 56 , no. 96 , pp. 15137-15140 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1296097329
- Document Type :
- Electronic Resource