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Chiral Resolution of Mandelic Acid through Preferential Cocrystallization with Nefiracetam
- Source :
- Crystal Growth & Design, Vol. 20, no.12, p. 7979-7988 (2020)
- Publication Year :
- 2020
-
Abstract
- In this paper, we identified a cocrystal conglomerate of mandelic acid using a drug compound as a coformer. We then developed a chiral resolution process based on preferential cocrystallization. Several versions of such a process were explored and optimized, leading to a successful resolution of mandelic acid, evidencing the efficiency of our system. Excellent enantiopurity (98–99%) was obtained with a process that can run for multiple cycles.
Details
- Database :
- OAIster
- Journal :
- Crystal Growth & Design, Vol. 20, no.12, p. 7979-7988 (2020)
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1288280794
- Document Type :
- Electronic Resource