Back to Search
Start Over
Hypertension, antihypertensive medication use, and breast cancer risk in the California teachers study cohort
- Source :
- Cancer Causes and Control; vol 21, iss 10, 1615-1624; 0957-5243
- Publication Year :
- 2010
-
Abstract
- Background: We investigated the association between hypertension, antihypertensive (AH) medication use, and breast cancer in a large prospective study, the California Teachers Study (CTS). Methods: Information on history of hypertension and lifetime regular use of AH medications was collected from 114,549 women in 1995-1996. Among them, 4,151 invasive breast cancers were diagnosed between 1995 and 2006. Additional information on AH use was collected from 73,742 women in 2000-2001, and 1,714 of these women were subsequently diagnosed with breast cancer. Cox proportional hazards regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) for breast cancer. Results: Use of AH medication for ≥5 years, when compared with no use, was associated with a modest increased risk of invasive breast cancer (RR = 1.18, 95%CI 1.02-1.36). This increased risk appeared to be confined to estrogen receptor (ER)-positive tumors (RR = 1.21, 95%CI 1.03-1.43) and pre-/peri-menopausal women (RR = 1.58, 95%CI 1.11-2.25). Conclusions: Increased risk of invasive breast cancer was observed for long-term (≥5 years) AH use, and this appeared to be confined to ER + breast cancer and younger women. © 2010 The Author(s).
Details
- Database :
- OAIster
- Journal :
- Cancer Causes and Control; vol 21, iss 10, 1615-1624; 0957-5243
- Notes :
- application/pdf, Cancer Causes and Control vol 21, iss 10, 1615-1624 0957-5243
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1287476137
- Document Type :
- Electronic Resource