Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis

See Giovannoni (doi:10.1093/brain/awy200) for a scientific commentary on this article. Biomarkers of tissue damage in multiple sclerosis are urgently needed. Barro et al. show that serum neurofilament light chain (NfL) levels are increased in patients versus healthy controls and reflect radiological and clinical disease activity and progression. High serum NfL is associated with greater subsequent brain and spinal cord atrophy.