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Long-GRIN-Lens Microendoscopy Enabled by Wavefront Shaping for a Biomedical Microdevice: An Analytical Investigation

Authors :
Liu, Guigen
Kang, Jeon Woong
Jonas, Oliver
Liu, Guigen
Kang, Jeon Woong
Jonas, Oliver
Source :
Multidisciplinary Digital Publishing Institute
Publication Year :
2021

Abstract

We analytically investigate the feasibility of long graded-index (GRIN)-lens-based microendoscopes through wavefront shaping. Following the very well-defined ray trajectories in a GRIN lens, mode-dependent phase delay is first determined. Then, the phase compensation needed for obtaining diffraction limited resolution is derived. Finally, the diffraction pattern of the lens output is computed using the Rayleigh–Sommerfeld diffraction theory. We show that diffraction-limited resolution is obtained for a 0.5 mm diameter lens with a length over 1 m. It is also demonstrated that different imaging working distances (WDs) can be realized by modifying the phase compensation. When a short design WD is used, a large imaging numerical aperture (NA) higher than 0.4 is achievable even when a low NA lens (NA = 0.1) is used. The long- and thin-GRIN-lens-based microendoscope investigated here, which is attractive for biomedical applications, is being prioritized for use in a clinical stage microdevice that measures three-dimensional drug responses inside the body. The advance described in this work may enable superior imaging capabilities in clinical applications in which long and flexible imaging probes are favored.

Details

Database :
OAIster
Journal :
Multidisciplinary Digital Publishing Institute
Notes :
application/pdf
Publication Type :
Electronic Resource
Accession number :
edsoai.on1286404372
Document Type :
Electronic Resource