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Guidance Level for Brevetoxins in French Shellfish

Authors :
Arnich, Nathalie
Abadie, Eric
Amzil, Zouher
Dechraoui Bottein, Marie-yasmine
Comte, Katia
Chaix, Estelle
Delcourt, Nicolas
Hort, Vincent
Mattei, César
Molgó, Jordi
Le Garrec, Raphaele
Arnich, Nathalie
Abadie, Eric
Amzil, Zouher
Dechraoui Bottein, Marie-yasmine
Comte, Katia
Chaix, Estelle
Delcourt, Nicolas
Hort, Vincent
Mattei, César
Molgó, Jordi
Le Garrec, Raphaele
Source :
Marine Drugs (1660-3397) (MDPI AG), 2021-09 , Vol. 19 , N. 9 , P. 520 (15p.)
Publication Year :
2021

Abstract

Brevetoxins (BTXs) are marine biotoxins responsible for neurotoxic shellfish poisoning (NSP) after ingestion of contaminated shellfish. NSP is characterized by neurological, gastrointestinal and/or cardiovascular symptoms. The main known producer of BTXs is the dinoflagellate Karenia brevis, but other microalgae are also suspected to synthesize BTX-like compounds. BTXs are currently not regulated in France and in Europe. In November 2018, they have been detected for the first time in France in mussels from a lagoon in the Corsica Island (Mediterranean Sea), as part of the network for monitoring the emergence of marine biotoxins in shellfish. To prevent health risks associated with the consumption of shellfish contaminated with BTXs in France, a working group was set up by the French Agency for Food, Environmental and Occupational Health & Safety (Anses). One of the aims of this working group was to propose a guidance level for the presence of BTXs in shellfish. Toxicological data were too limited to derive an acute oral reference dose (ARfD). Based on human case reports, we identified two lowest-observed-adverse-effect levels (LOAELs). A guidance level of 180 µg BTX-3 eq./kg shellfish meat is proposed, considering a protective default portion size of 400 g shellfish meat.

Details

Database :
OAIster
Journal :
Marine Drugs (1660-3397) (MDPI AG), 2021-09 , Vol. 19 , N. 9 , P. 520 (15p.)
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1286178208
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.3390.md19090520