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Separation of cognitive impairments in attention-deficit/hyperactivity disorder into 2 familial factors.
- Source :
- Archives of General Psychiatry; 1159; 1167; 0003-990X; 11; 67; ~Archives of General Psychiatry~1159~1167~~~0003-990X~11~67~~
- Publication Year :
- 2010
-
Abstract
- 1 november 2010<br />Contains fulltext : 89304.pdf (publisher's version ) (Open Access)<br />CONTEXT: Attention-deficit/hyperactivity disorder (ADHD) is associated with widespread cognitive impairments, but it is not known whether the apparent multiple impairments share etiological roots or separate etiological pathways exist. A better understanding of the etiological pathways is important for the development of targeted interventions and for identification of suitable intermediate phenotypes for molecular genetic investigations. OBJECTIVES: To determine, by using a multivariate familial factor analysis approach, whether 1 or more familial factors underlie the slow and variable reaction times, impaired response inhibition, and choice impulsivity associated with ADHD. DESIGN: An ADHD and control sibling-pair design. SETTING: Belgium, Germany, Ireland, Israel, Spain, Switzerland, and the United Kingdom. PARTICIPANTS: A total of 1265 participants, aged 6 to 18 years: 464 probands with ADHD and 456 of their siblings (524 with combined-subtype ADHD), and 345 control participants. MAIN OUTCOME MEASURES: Performance on a 4-choice reaction time task, a go/no-go inhibition task, and a choice-delay task. RESULTS: The final model consisted of 2 familial factors. The larger factor, reflecting 85% of the familial variance of ADHD, captured 98% to 100% of the familial influences on mean reaction time and reaction time variability. The second, smaller factor, reflecting 13% of the familial variance of ADHD, captured 62% to 82% of the familial influences on commission and omission errors on the go/no-go task. Choice impulsivity was excluded in the final model because of poor fit. CONCLUSIONS: The findings suggest the existence of 2 familial pathways to cognitive impairments in ADHD and indicate promising cognitive targets for future molecular genetic investigations. The familial distinction between the 2 cognitive impairments is consistent with recent theoretical models--a developmental model and an arousal-attention model--of 2 separable underlying processes in ADHD. Futu
Details
- Database :
- OAIster
- Journal :
- Archives of General Psychiatry; 1159; 1167; 0003-990X; 11; 67; ~Archives of General Psychiatry~1159~1167~~~0003-990X~11~67~~
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1284150602
- Document Type :
- Electronic Resource