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Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.

Authors :
Gudmundsson, J.
Sulem, P.
Rafnar, T.
Bergthorsson, J.T.
Manolescu, A.
Gudbjartsson, D.F.
Agnarsson, B.A.
Sigurdsson, A.
Benediktsdottir, K.R.
Blondal, T.
Jakobsdottir, M.
Stacey, S.N.
Kostic, J.
Kristinsson, K.T.
Birgisdottir, B.
Ghosh, S.
Magnusdottir, D.
Thorlacius, S.
Thorleifsson, G.
Zheng, S.L.
Sun, J.
Chang, B.L.
Elmore, J.B.
Breyer, J.P.
McReynolds, K.M.
Bradley, K.M.
Yaspan, B.L.
Wiklund, F.
Stattin, P
Lindstrom, S.
Adami, H.O.
McDonnell, S.K.
Schaid, D.J.
Cunningham, J.M.
Wang, L.
Cerhan, J.R.
Sauver, J.L. St
Isaacs, S.D.
Wiley, K.E.
Partin, A.W.
Walsh, P.C.
Polo, S.
Ruiz-Echarri, M.
Navarrete, S.
Fuertes, F.
Saez, B.
Godino, J.
Weijerman, P.C.
Swinkels, D.W.
Aben, K.K.H.
Witjes, J.A.
Suarez, B.K.
Helfand, B.T.
Frigge, M.L.
Kristjansson, K.
Ober, C.
Jonsson, E.
Einarsson, G.V.
Xu, J.
Gronberg, H.
Smith, J.R.
Thibodeau, S.N.
Isaacs, W.B.
Catalona, W.J.
Mayordomo, J.I.
Kiemeney, L.A.L.M.
Barkardottir, R.B.
Gulcher, J.R.
Thorsteinsdottir, U.
Kong, A.
Stefansson, K.
Gudmundsson, J.
Sulem, P.
Rafnar, T.
Bergthorsson, J.T.
Manolescu, A.
Gudbjartsson, D.F.
Agnarsson, B.A.
Sigurdsson, A.
Benediktsdottir, K.R.
Blondal, T.
Jakobsdottir, M.
Stacey, S.N.
Kostic, J.
Kristinsson, K.T.
Birgisdottir, B.
Ghosh, S.
Magnusdottir, D.
Thorlacius, S.
Thorleifsson, G.
Zheng, S.L.
Sun, J.
Chang, B.L.
Elmore, J.B.
Breyer, J.P.
McReynolds, K.M.
Bradley, K.M.
Yaspan, B.L.
Wiklund, F.
Stattin, P
Lindstrom, S.
Adami, H.O.
McDonnell, S.K.
Schaid, D.J.
Cunningham, J.M.
Wang, L.
Cerhan, J.R.
Sauver, J.L. St
Isaacs, S.D.
Wiley, K.E.
Partin, A.W.
Walsh, P.C.
Polo, S.
Ruiz-Echarri, M.
Navarrete, S.
Fuertes, F.
Saez, B.
Godino, J.
Weijerman, P.C.
Swinkels, D.W.
Aben, K.K.H.
Witjes, J.A.
Suarez, B.K.
Helfand, B.T.
Frigge, M.L.
Kristjansson, K.
Ober, C.
Jonsson, E.
Einarsson, G.V.
Xu, J.
Gronberg, H.
Smith, J.R.
Thibodeau, S.N.
Isaacs, W.B.
Catalona, W.J.
Mayordomo, J.I.
Kiemeney, L.A.L.M.
Barkardottir, R.B.
Gulcher, J.R.
Thorsteinsdottir, U.
Kong, A.
Stefansson, K.
Source :
Nature Genetics; 281; 283; 1061-4036; 3; 40; ~Nature Genetics~281~283~~~1061-4036~3~40~~
Publication Year :
2008

Abstract

Contains fulltext : 70723.pdf (publisher's version ) (Closed access)<br />We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.

Details

Database :
OAIster
Journal :
Nature Genetics; 281; 283; 1061-4036; 3; 40; ~Nature Genetics~281~283~~~1061-4036~3~40~~
Publication Type :
Electronic Resource
Accession number :
edsoai.on1284142641
Document Type :
Electronic Resource

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