Common variants at 11p13 are associated with susceptibility to tuberculosis.

Authors :: Thye, T.
Owusu-Dabo, E.
Vannberg, F.O.
Crevel, R. van
Curtis, J.
Sahiratmadja, E.
Balabanova, Y.
Ehmen, C.
Muntau, B.
Ruge, G.
Sievertsen, J.
Gyapong, J.
Nikolayevskyy, V.
Hill, P.C.
Sirugo, G.
Drobniewski, F.
Vosse, E. van de
Newport, M.
Alisjahbana, B.
Nejentsev, S.
Ottenhoff, T.H.
Hill, A.V.
Horstmann, R.D.
Meyer, C.G.
Thye, T.
Owusu-Dabo, E.
Vannberg, F.O.
Crevel, R. van
Curtis, J.
Sahiratmadja, E.
Balabanova, Y.
Ehmen, C.
Muntau, B.
Ruge, G.
Sievertsen, J.
Gyapong, J.
Nikolayevskyy, V.
Hill, P.C.
Sirugo, G.
Drobniewski, F.
Vosse, E. van de
Newport, M.
Alisjahbana, B.
Nejentsev, S.
Ottenhoff, T.H.
Hill, A.V.
Horstmann, R.D.
Meyer, C.G.
Source :: Nature Genetics; 257; 259; 1061-4036; 3; 44; ~Nature Genetics~257~259~~~1061-4036~3~44~~
Publication Year :: 2012
Abstract: 1 maart 2012<br />Item does not contain fulltext<br />After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 x 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 x 10(-11).

Database :: OAIster
Journal :: Nature Genetics; 257; 259; 1061-4036; 3; 44; ~Nature Genetics~257~259~~~1061-4036~3~44~~
Publication Type :: Electronic Resource
Accession number :: edsoai.on1284126591
Document Type :: Electronic Resource