DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts

Authors :: Chouliaras, L.
Kenis, G.
Visser, P.J.
Scheltens, P.
Tsolaki, M.
Jones, R.W.
Kehoe, P.G.
Graff, C.
Girtler, N.G.
Wallin, A.K.
Olde Rikkert, M.G.M.
Spiru, L.
Elias-Sonnenschein, L.S.
Ramakers, I.H.
Pishva, E.
Os, J. van
Steinbusch, H.W.
Verhey, F.R.J.
Hove, D.L. van den
Rutten, B.P.F.
Chouliaras, L.
Kenis, G.
Visser, P.J.
Scheltens, P.
Tsolaki, M.
Jones, R.W.
Kehoe, P.G.
Graff, C.
Girtler, N.G.
Wallin, A.K.
Olde Rikkert, M.G.M.
Spiru, L.
Elias-Sonnenschein, L.S.
Ramakers, I.H.
Pishva, E.
Os, J. van
Steinbusch, H.W.
Verhey, F.R.J.
Hove, D.L. van den
Rutten, B.P.F.
Source :: Epigenomics; 533; 537; 1750-1911; 4; 7; ~Epigenomics~533~537~~~1750-1911~4~7~~
Publication Year :: 2015
Abstract: Item does not contain fulltext<br />Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.

Database :: OAIster
Journal :: Epigenomics; 533; 537; 1750-1911; 4; 7; ~Epigenomics~533~537~~~1750-1911~4~7~~
Publication Type :: Electronic Resource
Accession number :: edsoai.on1284123235
Document Type :: Electronic Resource

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