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Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review
- Source :
- Advances in Therapy; 357; 68; 0741-238X; 3; vol. 33; ~Advances in Therapy~357~68~~~0741-238X~3~33~~
- Publication Year :
- 2016
-
Abstract
- Contains fulltext : 172098.pdf (Publisher’s version ) (Open Access)<br />Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.
Details
- Database :
- OAIster
- Journal :
- Advances in Therapy; 357; 68; 0741-238X; 3; vol. 33; ~Advances in Therapy~357~68~~~0741-238X~3~33~~
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1284070254
- Document Type :
- Electronic Resource