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Two-Stage Testing for Epistasis: Screening and Verification
- Source :
- Methods in Molecular Biology; 69; 92; 1064-3745; vol. 2212; ~Methods in Molecular Biology~69~92~~~1064-3745~~2212~~
- Publication Year :
- 2021
-
Abstract
- Item does not contain fulltext<br />Undiscovered gene-to-gene interaction (epistasis) is a possible explanation for the "missing heritability" of complex traits and diseases. On a genome-wide scale, screening for epistatic effects among all possible pairs of genetic markers faces two main complications. Firstly, the classical statistical methods for modeling epistasis are computationally very expensive, which makes them impractical on such large scale. Secondly, straightforward corrections for multiple testing using the classical methods tend to be too coarse and inefficient at discovering the epistatic effects in such a large scale application. In this chapter, we describe both the underlying framework and practical examples of two-stage statistical testing methods that alleviate both of the aforementioned complications.
Details
- Database :
- OAIster
- Journal :
- Methods in Molecular Biology; 69; 92; 1064-3745; vol. 2212; ~Methods in Molecular Biology~69~92~~~1064-3745~~2212~~
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1284067970
- Document Type :
- Electronic Resource