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Inflammatory markers and the risk of dementia and Alzheimer's disease: A meta-analysis
- Source :
- Alzheimer's & Dementia; 1450; 1459; 1552-5260; 11; 14; ~Alzheimer's & Dementia~1450~1459~~~1552-5260~11~14~~
- Publication Year :
- 2018
-
Abstract
- Item does not contain fulltext<br />INTRODUCTION: Inflammatory markers are often elevated in patients with dementia, including Alzheimer's disease (AD). However, it remains unclear whether inflammatory markers are associated with the risk of developing dementia. METHODS: We searched PubMed, Embase, and Cochrane library for prospective population-based studies reporting associations between inflammatory markers and all-cause dementia or AD. We used random effects meta-analyses to obtain pooled hazard ratios (HRs) and 95% confidence intervals of inflammatory markers (highest vs. lowest quantile) for all-cause dementia and AD. RESULTS: Fifteen articles from 13 studies in six countries reported data that could be meta-analyzed. C-reactive protein (HR = 1.37 [1.05; 1.78]), interleukin-6 (HR = 1.40 [1.13; 1.73]), alpha1-antichymotrypsin (HR = 1.54 [1.14; 2.80]), lipoprotein-associated phospholipase A2 activity (HR = 1.40 [1.03; 1.90]), and fibrinogen were each associated with all-cause dementia, but neither was significantly associated with AD. DISCUSSION: Several inflammatory markers are associated with an increased risk of all-cause dementia; however, these markers are not specific for AD. Whether inflammatory markers closely involved in AD pathology are associated with the risk of AD remains to be elucidated.
Details
- Database :
- OAIster
- Journal :
- Alzheimer's & Dementia; 1450; 1459; 1552-5260; 11; 14; ~Alzheimer's & Dementia~1450~1459~~~1552-5260~11~14~~
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1284065566
- Document Type :
- Electronic Resource