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Long-Term Quality of Life in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma
- Source :
- Journal of Clinical Endocrinology and Metabolism; 1218; 1226; 0021-972X; 4; 102; ~Journal of Clinical Endocrinology and Metabolism~1218~1226~~~0021-972X~4~102~~
- Publication Year :
- 2017
-
Abstract
- Contains fulltext : 174769.pdf (publisher's version ) (Open Access)<br />Context: Little is known about long-term quality of life (QoL) of survivors of pediatric differentiated thyroid carcinoma. Therefore, this study aimed to evaluate generic health-related QoL (HRQoL), fatigue, anxiety, and depression in these survivors compared with matched controls, and to evaluate thyroid cancer-specific HRQoL in survivors only. Design: Survivors diagnosed between 1970 and 2013 at age </=18 years, were included. Exclusion criteria were a follow-up <5 years, attained age <18 years, or diagnosis of DTC as a second malignant neoplasm (SMN). Controls were matched by age, sex, and socioeconomic status. Survivors and controls were asked to complete 3 questionnaires [Short-Form 36 (HRQoL), Multidimensional Fatigue Inventory 20 (fatigue), and Hospital Anxiety and Depression Scale (anxiety/depression)]. Survivors completed a thyroid cancer-specific HRQoL questionnaire. Results: Sixty-seven survivors and 56 controls. Median age of survivors at evaluation was 34.2 years (range, 18.8 to 61.7). Median follow-up was 17.8 years (range, 5.0 to 44.7). On most QoL subscales, scores of survivors and controls did not differ significantly. However, survivors had more physical problems (P = 0.031), role limitations due to physical problems (P = 0.021), and mental fatigue (P = 0.016) than controls. Some thyroid cancer-specific complaints (e.g., sensory complaints and chilliness) were present in survivors. Unemployment and more extensive disease or treatment characteristics were most frequently associated with worse QoL. Conclusions: Overall, long-term QoL in survivors of pediatric DTC was normal. Survivors experienced mild impairment of QoL in some domains (physical problems, mental fatigue, and various thyroid cancer-specific complaints). Factors possibly affecting QoL need further exploration.
Details
- Database :
- OAIster
- Journal :
- Journal of Clinical Endocrinology and Metabolism; 1218; 1226; 0021-972X; 4; 102; ~Journal of Clinical Endocrinology and Metabolism~1218~1226~~~0021-972X~4~102~~
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1284041281
- Document Type :
- Electronic Resource