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Oral contraception does not alter typical post-exercise interleukin-6 and hepcidin levels in females
- Source :
- Journal of Science and Medicine in Sport; 8; 12; 1440-2440; 1; 18; ~Journal of Science and Medicine in Sport~8~12~~~1440-2440~1~18~~
- Publication Year :
- 2015
-
Abstract
- Item does not contain fulltext<br />OBJECTIVES: The post-exercise interleukin-6 (IL-6) and hepcidin response was investigated during the hormone-deplete and hormone-replete phases of an estradiol and progestogen regulated oral contraceptive cycle (OCC). DESIGN: Counterbalanced, repeated measures cross-over study. METHODS: Ten active female monophasic oral contraceptive pill (OCP) users completed two 40 min treadmill running trials at 75% of their pre-determined peak oxygen uptake velocity (vVO2peak). These trials were randomly performed in two specific phases of the OCC: (a) Day 2-4, representing a hormone-free withdrawal period (D-0); (b) Day 12-14, representing the end of the first week of active hormone therapy (D+7). Venous blood samples were drawn pre-, post- and 3h post-exercise. RESULTS: In both trials, serum IL-6 was significantly elevated (p<0.05) immediately post-exercise, while serum hepcidin was significantly elevated (p<0.05) 3h post-exercise, with no significant differences recorded between trials. CONCLUSIONS: These findings suggest that exercise performed during the different phases (D-0 vs. D+7) of a monophasic OCP regulated cycle does not alter exercise induced IL-6 or hepcidin production. As such, future studies looking to investigate similar variables post-exercise, may not need to 'control' for different phases of the OCC, provided participants are current monophasic OCP users.
Details
- Database :
- OAIster
- Journal :
- Journal of Science and Medicine in Sport; 8; 12; 1440-2440; 1; 18; ~Journal of Science and Medicine in Sport~8~12~~~1440-2440~1~18~~
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1284018836
- Document Type :
- Electronic Resource