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In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts
- Source :
- Perentes , J Y , McKee , T D , Ley , C D , Mathiew , H , Dawson , M , Padera , T P , Munn , L L , Jain , R K & Boucher , Y 2009 , ' In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts ' , Nature Methods , vol. 6 , no. 2 , pp. 143-5 .
- Publication Year :
- 2009
-
Abstract
- Udgivelsesdato: 2009-Feb<br />Here we integrated multiphoton laser scanning microscopy and the registration of second harmonic generation images of collagen fibers to overcome difficulties in tracking stromal cell-matrix interactions for several days in live mice. We show that the matrix-modifying hormone relaxin increased tumor-associated fibroblast (TAF) interaction with collagen fibers by stimulating beta1-integrin activity, which is necessary for fiber remodeling by matrix metalloproteinases.
Details
- Database :
- OAIster
- Journal :
- Perentes , J Y , McKee , T D , Ley , C D , Mathiew , H , Dawson , M , Padera , T P , Munn , L L , Jain , R K & Boucher , Y 2009 , ' In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts ' , Nature Methods , vol. 6 , no. 2 , pp. 143-5 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1283994718
- Document Type :
- Electronic Resource