Comparison of the multi-phasic longitudinal displacement of the left and right common carotid artery in healthy humans

Background During the cardiac cycle, there is a multi-phasic bidirectional longitudinal movement (LMov) of the intima-media complex of large arteries, i.e. along the arteries. On the left side the common carotid artery (CCA) arises directly from the aortic arc, whereas on the right side the CCA originate from the innominate artery. Aim The aim of this study was to compare LMov of the left and right CCA of healthy subjects to investigate whether the difference in anatomy is of importance for LMov. Material and Methods The CCAs of 93 healthy subjects were investigated using in-house developed ultrasound methods. Results Although the basic pattern were the same in the majority of subjects, several phases of LMov were significantly larger on the left side (the first retrograde phase, p = 0.0006; the second antegrade, "returning" phase, p < 0.00001; and the rapid retrograde phase of movement at the end of the cardiac cycle, p < 0.000001). In contrast, no significant side-difference in the amplitude of the first antegrade movement was seen. The maximal (peak-to-peak) LMov was significantly larger on the left side (p = 0.002). Discussion and Conclusion The side-differences found in LMov may be related to the difference in anatomy, including possible difference in distance to the heart and especially the presence of an extra bifurcation on the right side. Our data provide an important base for the further study of the relation between LMov and cardiovascular risk factors and atherosclerosis.
Funding Agencies|Heart Lung Foundation, SwedenSwedish Heart-Lung Foundation; Medical Faculty; Lund University; Swedish Research CouncilSwedish Research CouncilEuropean Commission; Skane County Research Council; Skane University Hospital; Region Ostergotland