Evaluation of Bioactive Release Kinetics from Crosslinked Chitosan Films with Aloe Vera

Thermocompression was employed to prepare citric acid-crosslinked chitosan films with Aloe vera (AV) as bioactive compound. Films were easy to handle and mechanical properties did not change with the addition of AV up to 10 wt%, although both TS and EAB decreased for the films with 15 wt% AV, indicating that high AV contents would hinder intermolecular interactions among the formulation components. Maillard reaction occurred between chitosan and citric acid at the processing temperature used (115 °C), while physical interactions took place with AV, as shown by FTIR analysis. All films were insoluble but displayed hydration and limited swelling due to both physical and chemical interactions promoted by AV and citric acid, respectively. A slow AV release, governed by a Fickian diffusion controlled mechanism, and an increase of surface hydrophilicity, which favors cell adhesion, were observed.