Back to Search Start Over

Experimental Study on Patient Preferences Regarding the Shape and Size of Medical Tablets and Capsules Using Three-Dimensionally Printed Plastic Model Formulations

Experimental Study on Patient Preferences Regarding the Shape and Size of Medical Tablets and Capsules Using Three-Dimensionally Printed Plastic Model Formulations

Authors :
Kabeya,Kenji
Satoh,Hiroki
Hori,Satoko
Sawada,Yasufumi
Kabeya,Kenji
Satoh,Hiroki
Hori,Satoko
Sawada,Yasufumi
Publication Year :
2021

Abstract

Kenji Kabeya,1 Hiroki Satoh,2,3 Satoko Hori,4 Yasufumi Sawada2 1Faculty of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan; 2Laboratory of Drug Lifetime Management, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan; 3Interfaculty Initiative in Information Studies, The University of Tokyo, Tokyo, 113-0033, Japan; 4Laboratory of Drug Informatics, Keio University Faculty of Pharmacy, Tokyo, 105-8512, JapanCorrespondence: Yasufumi Sawada Tel +81 3 5841 1096Fax +81 3 5841 1097Email sawada@mol.f.u-tokyo.ac.jpBackground: Tablets and capsules are the most common dosage forms. However, ease of use and/or swallowing influences patients’ compliance.Objective: To identify patients’ preferences regarding the three-dimensional size of medical tablets/capsules.Methods: Eighteen cylindrical-, oblong-, and oval-shaped model formulations having different sizes were prepared by three-dimensional printing using polylactic acid. Participants (40 patients visiting a pharmacy in Japan) evaluated the difficulty of picking up and swallowing these model formulations by touching/observing them, and completed a questionnaire. The visual analogue scale (VAS) was used to evaluate each sample, and the relationship of VAS scores to the major axis, thickness, I2 (the sum of major/minor axes) and I3 (the sum of major/minor axes and thickness) of the model formulations was evaluated by ANOVA followed by Tukey’s test.Results: Female participants showed lower VAS scores (less difficult) for picking difficulty compared with male participants, and those taking many drugs showed higher VAS scores (more difficult) for swallowing difficulty compared with those taking fewer drugs. Otherwise, age, gender, disease status, number of drugs usually taken, and ingestion problems did not greatly influence the evaluation. Overall, larger model formulations showed less picking difficulty, but greater swallowing difficulty

Details

Database :
OAIster
Notes :
text/html, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1252759677
Document Type :
Electronic Resource