A Comparative Study of Macular and Choroidal Thickness and Blood-Flow Parameters in Patients with Intermediate and Simple Juvenile Moderate Myopia

TaiNan Lin,1,* Yan Yang,2,* JinHua Lin,1 JiHui Zhang,1 Qian Wen,1 XiaoLu He,1 GuoQing Chen1 1Department of Ophthalmology, Fujian Provincial Governmental Hospital, Fuzhou, 350003, People’s Republic of China; 2Fujian Center for Disease Control and Prevention, Fuzhou, 350001, People’s Republic of China*These authors contributed equally to this workCorrespondence: TaiNan LinDepartment of Ophthalmology, Fujian Provincial Governmental Hospital, No. 67 of Gupin Street, Gulou District, Fuzhou, 350003, People’s Republic of ChinaTel +86 591 88013047Fax +86 591 88013003Email lintainandr@163.comObjective: This study aimed to compare the macular and choroidal thicknesses and blood-flow parameters of patients with intermediate and simple juvenile moderate myopia in order to provide a greater understanding of the pathogenesis of myopia and a basis for its prevention.Methods: Participants were selected from patients under the age of 18 with moderate myopia who were treated in our ophthalmic clinic between June and December 2019. Seventy-five right eyes were selected from participants with a mean spherical equivalent ranging from − 6.0 to − 3.0 D. These samples were divided into two groups based on eye axial length (AL). The thicknesses of the macula and choroid, the area of the foveal avascular zone (FAZ), and the blood flow density of the macular capillaries were measured, intergroup comparison was conducted.Results: The average area of the FAZ was larger in the intermediate group than in the simple group. PERIM in the upper half was lower in the intermediate group than in the simple group, and the blood-flow density in the lower half of the macular area was higher in the simple group than in the intermediate group. The blood-flow density within 1 mm of the fovea centralis and the downward blood-flow density were higher in the intermediate group than in the simple group. The thicknesses of the lower part of the FAZ, the choroid of