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Modeling External Stimulation of Excitable Cells Using a Novel Light-Activated Organic Semiconductor Technology
- Publication Year :
- 2020
-
Abstract
- Optoelectronic neurostimulation is a promising, minimally invasive treatment modality for neuronal damage, in particular for patients with traumatic brain injury. In this work, a newly developed optoelectronic device, a so-called photocap, based on light-activated organic semiconductor structures with high spatial and temporal resolution is investigated. To prove and verify the feasibility of this new technology, a mathematical model was developed, simulating the electrical response of excitable cells to photocap stimulation. In the first step, a comprehensive technical review of the device concept was performed, building the basis for setting up the simulation model. The simulations demonstrate that photocaps may serve as a stimulation device, triggering action potentials in neural or cardiac cells. Our first results show that the model serves as a perfect tool for evaluating and further developing this new technology, showing high potential for introducing new and innovative therapy methods in the field of optoelectronic cell stimulation.<br />Funding agency: FWF Zukunftskolleg Program as part of the project“LOGOS-TBI: Light-controlled Organic Semiconductor Implants for Regeneration afterTBI” (Project ID: ZK-17)
Details
- Database :
- OAIster
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1248701856
- Document Type :
- Electronic Resource
- Full Text :
- https://doi.org/10.3233.SHTI200068