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Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes

Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes

Authors :
Csengeri, Dora
Sprünker, Ngoc-Anh
Niiranen, Teemu
Vishram-Nielsen, Julie Kk.
Costanzo, Simona
Söderberg, Stefan
Jensen, Steen M.
Vartiainen, Erkki
Donati, Maria Benedetta
Magnussen, Christina
Camen, Stephan
Gianfagna, Francesco
Løchen, Maja-Lisa
Kee, Frank
Kontto, Jukka
Mathiesen, Ellisiv B.
Koenig, Wolfgang
Stefan, Blankenberg
de Gaetano, Giovanni
Jørgensen, Torben
Kuulasmaa, Kari
Zeller, Tanja
Salomaa, Veikko
Iacoviello, Licia
Schnabel, Renate B.
Csengeri, Dora
Sprünker, Ngoc-Anh
Niiranen, Teemu
Vishram-Nielsen, Julie Kk.
Costanzo, Simona
Söderberg, Stefan
Jensen, Steen M.
Vartiainen, Erkki
Donati, Maria Benedetta
Magnussen, Christina
Camen, Stephan
Gianfagna, Francesco
Løchen, Maja-Lisa
Kee, Frank
Kontto, Jukka
Mathiesen, Ellisiv B.
Koenig, Wolfgang
Stefan, Blankenberg
de Gaetano, Giovanni
Jørgensen, Torben
Kuulasmaa, Kari
Zeller, Tanja
Salomaa, Veikko
Iacoviello, Licia
Schnabel, Renate B.
Publication Year :
2021

Abstract

AIMS: There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts. METHODS AND RESULTS: In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11-1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF. CONCLUSIONS: In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention.

Details

Database :
OAIster
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1247752040
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1093.eurheartj.ehaa953