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The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria

Authors :
Skinner-Adams, TS
Peatey, CL
Anderson, K
Trenholme, KR
Krige, D
Brown, CL
Stack, C
Nsangou, DMM
Mathews, RT
Thivierge, K
Dalton, JP
Gardiner, DL
Skinner-Adams, TS
Peatey, CL
Anderson, K
Trenholme, KR
Krige, D
Brown, CL
Stack, C
Nsangou, DMM
Mathews, RT
Thivierge, K
Dalton, JP
Gardiner, DL
Publication Year :
2012

Abstract

Malaria remains a significant risk in many areas of the world, with resistance to the current antimalarial pharmacopeia an everincreasing problem. The M1 alanine aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) are believed to play a role in the terminal stages of digestion of host hemoglobin and thereby generate a pool of free amino acids that are essential for parasite growth and development. Here, we show that an orally bioavailable aminopeptidase inhibitor, CHR-2863, is efficacious against murine malaria. Copyright © 2012, American Society for Microbiology. All Rights Reserved.

Details

Database :
OAIster
Publication Type :
Electronic Resource
Accession number :
edsoai.on1242994326
Document Type :
Electronic Resource