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Neuropsychiatric Correlates of Small Vessel Disease Progression in Incident Cognitive Decline: Independent and Interactive Effects
- Publication Year :
- 2020
-
Abstract
- BACKGROUND: Cerebral small vessel disease (SVD) and neuropsychiatric symptoms (NPS) independently increase the risk of cognitive decline. While their co-existence has been reported in the preclinical stage of dementia, longitudinal data establishing the prognosis of their associations, especially in an Asian context remains limited. OBJECTIVE: This study investigated the role of SVD and NPS progressions on cognitive outcomes over 2 years in a dementia-free elderly cohort. METHODS: 170 dementia-free elderly with baseline and 2-year neuropsychological assessments and MRI scans were included in this study. White matter hyperintensities (WMH), lacunes, and microbleeds (CMBs) were graded as markers of SVD. The Neu
Details
- Database :
- OAIster
- Notes :
- application/pdf, Journal of Alzheimer's Disease vol. 73 no. 3, pp. 1053-1062, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1236257036
- Document Type :
- Electronic Resource
- Full Text :
- https://doi.org/10.3233.JAD-190999