Skip to search
Skip to main content
Back to Search
Start Over
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
Authors :
Franceschini, Nora Giambartolomei, Claudia de Vries, Paul S. Finan, Chris Bis, Joshua C. Huntley, Rachael P. Lovering, Ruth C. Tajuddin, Salman M. Winkler, Thomas W. Graff, Misa Kavousi, Maryam Dale, Caroline Smith, Albert V. Hofer, Edith van Leeuwen, Elisabeth M. Nolte, Ilja M. Lu, Lingyi Scholz, Markus Sargurupremraj, Muralidharan Pitkanen, Niina Franzen, Oscar Joshi, Peter K. Noordam, Raymond Marioni, Riccardo E. Hwang, Shih-Jen Musani, Solomon K. Schminke, Ulf Palmas, Walter Isaacs, Aaron Correa, Adolfo Zonderman, Alan B. Hofman, Albert Teumer, Alexander Cox, Amanda J. Uitterlinden, Andre G. Wong, Andrew Smit, Andries J. Newman, Anne B. Britton, Annie Ruusalepp, Arno Sennblad, Bengt Hedblad, Bo Pasaniuc, Bogdan Penninx, Brenda W. Langefeld, Carl D. Wassel, Christina L. Tzourio, Christophe Fava, Cristiano Baldassarre, Damiano O'Leary, Daniel H. Teupser, Daniel Kuh, Diana Tremoli, Elena Mannarino, Elmo Grossi, Enzo Boerwinkle, Eric Schadt, Eric E. Ingelsson, Erik Veglia, Fabrizio Rivadeneira, Fernando Beutner, Frank Chauhan, Ganesh Heiss, Gerardo Snieder, Harold Campbell, Harry Voelzke, Henry Markus, Hugh S. Deary, Ian J. Jukema, J. Wouter de Graaf, Jacqueline Price, Jacqueline Pott, Janne Hopewell, Jemma C. Liang, Jingjing Thiery, Joachim Engmann, Jorgen Gertow, Karl Rice, Kenneth Taylor, Kent D. Dhana, Klodian Kiemeney, Lambertus A. L. M. Lind, Lars Raffield, Laura M. Launer, Lenore J. Holdt, Lesca M. Doer, Marcus Dichgans, Martin Traylor, Matthew Sitzer, Matthias Kumari, Meena Kivimaki, Mika Nalls, Mike A. Melander, Olle Raitakari, Olli Franco, Oscar H. Rueda-Ochoa, Oscar L. Roussos, Panos Whincup, Peter H. Amouyel, Philippe Giral, Philippe Anugu, Pramod Wong, Quenna Malik, Rainer Rauramaa, Rainer Burkhardt, Ralph Hardy, Rebecca Schmidt, Reinhold de Mutsert, Renee Morris, Richard W. Strawbridge, Rona J. Wannamethee, S. Goya Hagg, Sara Shah, Sonia McLachlan, Stela Trompet, Stella Seshadri, Sudha Kurl, Sudhir Heckbert, Susan R. Ring, Susan Harris, Tamara B. Lehtimaki, Terho Galesloot, Tessel E. Shah, Tina de Faire, Ulf Plagnol, Vincent Rosamond, Wayne D. Post, Wendy Zhu, Xiaofeng Zhang, Xiaoling Guo, Xiuqing Saba, Yasaman Dehghan, Abbas Seldenrijk, Adrie Morrison, Alanna C. Hamsten, Anders Psaty, Bruce M. van Duijn, Cornelia M. Lawlor, Deborah A. Mook-Kanamori, Dennis O. Bowden, Donald W. Schmidt, Helena Wilson, James F. Wilson, James G. Rotter, Jerome I. Wardlaw, Joanna M. Deanfield, John Halcox, Julian Lyytikainen, Leo-Pekka Loeffler, Markus Evans, Michele K. Debette, Stephanie Humphries, Steve E. Voelker, Uwe Gudnason, Vilmundur Hingorani, Aroon D. Bjorkegren, Johan L. M. Casas, Juan P. O'Donnell, Christopher J. Franceschini, Nora Giambartolomei, Claudia de Vries, Paul S. Finan, Chris Bis, Joshua C. Huntley, Rachael P. Lovering, Ruth C. Tajuddin, Salman M. Winkler, Thomas W. Graff, Misa Kavousi, Maryam Dale, Caroline Smith, Albert V. Hofer, Edith van Leeuwen, Elisabeth M. Nolte, Ilja M. Lu, Lingyi Scholz, Markus Sargurupremraj, Muralidharan Pitkanen, Niina Franzen, Oscar Joshi, Peter K. Noordam, Raymond Marioni, Riccardo E. Hwang, Shih-Jen Musani, Solomon K. Schminke, Ulf Palmas, Walter Isaacs, Aaron Correa, Adolfo Zonderman, Alan B. Hofman, Albert Teumer, Alexander Cox, Amanda J. Uitterlinden, Andre G. Wong, Andrew Smit, Andries J. Newman, Anne B. Britton, Annie Ruusalepp, Arno Sennblad, Bengt Hedblad, Bo Pasaniuc, Bogdan Penninx, Brenda W. Langefeld, Carl D. Wassel, Christina L. Tzourio, Christophe Fava, Cristiano Baldassarre, Damiano O'Leary, Daniel H. Teupser, Daniel Kuh, Diana Tremoli, Elena Mannarino, Elmo Grossi, Enzo Boerwinkle, Eric Schadt, Eric E. Ingelsson, Erik Veglia, Fabrizio Rivadeneira, Fernando Beutner, Frank Chauhan, Ganesh Heiss, Gerardo Snieder, Harold Campbell, Harry Voelzke, Henry Markus, Hugh S. Deary, Ian J. Jukema, J. Wouter de Graaf, Jacqueline Price, Jacqueline Pott, Janne Hopewell, Jemma C. Liang, Jingjing Thiery, Joachim Engmann, Jorgen Gertow, Karl Rice, Kenneth Taylor, Kent D. Dhana, Klodian Kiemeney, Lambertus A. L. M. Lind, Lars Raffield, Laura M. Launer, Lenore J. Holdt, Lesca M. Doer, Marcus Dichgans, Martin Traylor, Matthew Sitzer, Matthias Kumari, Meena Kivimaki, Mika Nalls, Mike A. Melander, Olle Raitakari, Olli Franco, Oscar H. Rueda-Ochoa, Oscar L. Roussos, Panos Whincup, Peter H. Amouyel, Philippe Giral, Philippe Anugu, Pramod Wong, Quenna Malik, Rainer Rauramaa, Rainer Burkhardt, Ralph Hardy, Rebecca Schmidt, Reinhold de Mutsert, Renee Morris, Richard W. Strawbridge, Rona J. Wannamethee, S. Goya Hagg, Sara Shah, Sonia McLachlan, Stela Trompet, Stella Seshadri, Sudha Kurl, Sudhir Heckbert, Susan R. Ring, Susan Harris, Tamara B. Lehtimaki, Terho Galesloot, Tessel E. Shah, Tina de Faire, Ulf Plagnol, Vincent Rosamond, Wayne D. Post, Wendy Zhu, Xiaofeng Zhang, Xiaoling Guo, Xiuqing Saba, Yasaman Dehghan, Abbas Seldenrijk, Adrie Morrison, Alanna C. Hamsten, Anders Psaty, Bruce M. van Duijn, Cornelia M. Lawlor, Deborah A. Mook-Kanamori, Dennis O. Bowden, Donald W. Schmidt, Helena Wilson, James F. Wilson, James G. Rotter, Jerome I. Wardlaw, Joanna M. Deanfield, John Halcox, Julian Lyytikainen, Leo-Pekka Loeffler, Markus Evans, Michele K. Debette, Stephanie Humphries, Steve E. Voelker, Uwe Gudnason, Vilmundur Hingorani, Aroon D. Bjorkegren, Johan L. M. Casas, Juan P. O'Donnell, Christopher J.
Publication Year :
2018
Abstract
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.
Details
Database :
OAIster
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1235206933
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1038.s41467-018-07340-5