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Highly Selective Iridium-Catalyzed Asymmetric Hydrogenation of Trifluoromethyl Olefins : A New Route to Trifluoromethyl-Bearing Stereocenters
- Publication Year :
- 2009
-
Abstract
- Fluorine-containing compounds are useful in many applications ranging from pharmaceuticals to ferroelectric crystals. We have developed a new, highly enantioselective synthetic route to trifluoromethyl-bearing stereocenters in up to 96% ee via asymmetric hydrogenation using N,P-ligated iridium catalysts. We also hydrogenated an isomeric mixture of olefins; this reaction gave the hydrogenation product highly enantioselectively (87% ee), and only the E isomer was present after the reaction had reached 56% conversion.
Details
- Database :
- OAIster
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1235120007
- Document Type :
- Electronic Resource
- Full Text :
- https://doi.org/10.1002.adsc.200800645