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Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
Authors :
Wain, Louise V. Verwoert, Germaine C. O'Reilly, Paul F. Shi, Gang Johnson, Toby Johnson, Andrew D. Bochud, Murielle Rice, Kenneth M. Henneman, Peter Smith, Albert V. Ehret, Georg B. Amin, Najaf Larson, Martin G. Mooser, Vincent Hadley, David Doerr, Marcus Bis, Joshua C. Aspelund, Thor Esko, Tonu Janssens, A. Cecile J. W. Zhao, Jing Hua Heath, Simon Laan, Maris Fu, Jingyuan Pistis, Giorgio Luan, Jian'an Arora, Pankaj Lucas, Gavin Pirastu, Nicola Pichler, Irene Jackson, Anne U. Webster, Rebecca J. Zhang, Feng Peden, John F. Schmidt, Helena Tanaka, Toshiko Campbell, Harry Igl, Wilmar Milaneschi, Yuri Hottenga, Jouke-Jan Vitart, Veronique Chasman, Daniel I. Trompet, Stella Bragg-Gresham, Jennifer L. Alizadeh, Behrooz Z. Chambers, John C. Guo, Xiuqing Lehtimaki, Terho Kuehnel, Brigitte Lopez, Lorna M. Polasek, Ozren Boban, Mladen Nelson, Christopher P. Morrison, Alanna C. Pihur, Vasyl Ganesh, Santhi K. Hofman, Albert Kundu, Suman Mattace-Raso, Francesco U. S. Rivadeneira, Fernando Sijbrands, Eric J. G. Uitterlinden, Andre G. Hwang, Shih-Jen Vasan, Ramachandran S. Wang, Thomas J. Bergmann, Sven Vollenweider, Peter Waeber, Gerard Laitinen, Jaana Pouta, Anneli Zitting, Paavo McArdle, Wendy L. Kroemer, Heyo K. Voelker, Uwe Voelzke, Henry Glazer, Nicole L. Taylor, Kent D. Harris, Tamara B. Alavere, Helene Haller, Toomas Keis, Aime Tammesoo, Mari-Liis Aulchenko, Yurii Barroso, Ines Khaw, Kay-Tee Galan, Pilar Hercberg, Serge Lathrop, Mark Eyheramendy, Susana Org, Elin Sober, Siim Lu, Xiaowen Nolte, Ilja M. Penninx, Brenda W. Corre, Tanguy Masciullo, Corrado Sala, Cinzia Groop, Leif Voight, Benjamin F. Melander, Olle O'Donnell, Christopher J. Salomaa, Veikko d'Adamo, Adamo Pio Fabretto, Antonella Faletra, Flavio Ulivi, Sheila Del Greco, Fabiola M. Facheris, Maurizio Collins, Francis S. Bergman, Richard N. Beilby, John P. Hung, Joseph Musk, A. William Mangino, Massimo Shin, So-Youn Soranzo, Nicole Watkins, Hugh Goel, Anuj Hamsten, Anders Gider, Pierre Loitfelder, Marisa Zeginigg, Marion Hernandez, Dena Najjar, Samer S. Navarro, Pau Wild, Sarah H. Corsi, Anna Maria Singleton, Andrew de Geus, Eco J. C. Willemsen, Gonneke Parker, Alex N. Rose, Lynda M. Buckley, Brendan Stott, David Orru, Marco Uda, Manuela van der Klauw, Melanie M. Zhang, Weihua Li, Xinzhong Scott, James Chen, Yii-Der Ida Burke, Gregory L. Kahonen, Mika Viikari, Jorma Doering, Angela Meitinger, Thomas Davies, Gail Starr, John M. Emilsson, Valur Plump, Andrew Lindeman, Jan H. 't Hoen, Peter A. C. Koenig, Inke R. Felix, Janine F. Clarke, Robert Hopewell, Jemma C. Ongen, Halit Breteler, Monique Debette, Stephanie DeStefano, Anita L. Fornage, Myriam Mitchell, Gary F. Smith, Nicholas L. Holm, Hilma Stefansson, Kari Thorleifsson, Gudmar Thorsteinsdottir, Unnur Samani, Nilesh J. Preuss, Michael Rudan, Igor Hayward, Caroline Deary, Ian J. Wichmann, H-Erich Raitakari, Olli T. Palmas, Walter Kooner, Jaspal S. Stolk, Ronald P. Jukema, J. Wouter Wright, Alan F. Boomsma, Dorret I. Bandinelli, Stefania Gyllensten, Ulf B. Wilson, James F. Ferrucci, Luigi Schmidt, Reinhold Farrall, Martin Spector, Tim D. Palmer, Lyle J. Tuomilehto, Jaakko Pfeufer, Arne Gasparini, Paolo Siscovick, David Altshuler, David Loos, Ruth J. F. Toniolo, Daniela Snieder, Harold Gieger, Christian Meneton, Pierre Wareham, Nicholas J. Oostra, Ben A. Metspalu, Andres Launer, Lenore Rettig, Rainer Strachan, David P. Beckmann, Jacques S. Witteman, Jacqueline C. M. Erdmann, Jeanette van Dijk, Ko Willems Boerwinkle, Eric Boehnke, Michael Ridker, Paul M. Jarvelin, Marjo-Riitta Chakravarti, Aravinda Abecasis, Goncalo R. Gudnason, Vilmundur Newton-Cheh, Christopher Levy, Daniel Munroe, Patricia B. Psaty, Bruce M. Caulfield, Mark J. Rao, Dabeeru C. Tobin, Martin D. Elliott, Paul van Duijn, Cornelia M. Wain, Louise V. Verwoert, Germaine C. O'Reilly, Paul F. Shi, Gang Johnson, Toby Johnson, Andrew D. Bochud, Murielle Rice, Kenneth M. Henneman, Peter Smith, Albert V. Ehret, Georg B. Amin, Najaf Larson, Martin G. Mooser, Vincent Hadley, David Doerr, Marcus Bis, Joshua C. Aspelund, Thor Esko, Tonu Janssens, A. Cecile J. W. Zhao, Jing Hua Heath, Simon Laan, Maris Fu, Jingyuan Pistis, Giorgio Luan, Jian'an Arora, Pankaj Lucas, Gavin Pirastu, Nicola Pichler, Irene Jackson, Anne U. Webster, Rebecca J. Zhang, Feng Peden, John F. Schmidt, Helena Tanaka, Toshiko Campbell, Harry Igl, Wilmar Milaneschi, Yuri Hottenga, Jouke-Jan Vitart, Veronique Chasman, Daniel I. Trompet, Stella Bragg-Gresham, Jennifer L. Alizadeh, Behrooz Z. Chambers, John C. Guo, Xiuqing Lehtimaki, Terho Kuehnel, Brigitte Lopez, Lorna M. Polasek, Ozren Boban, Mladen Nelson, Christopher P. Morrison, Alanna C. Pihur, Vasyl Ganesh, Santhi K. Hofman, Albert Kundu, Suman Mattace-Raso, Francesco U. S. Rivadeneira, Fernando Sijbrands, Eric J. G. Uitterlinden, Andre G. Hwang, Shih-Jen Vasan, Ramachandran S. Wang, Thomas J. Bergmann, Sven Vollenweider, Peter Waeber, Gerard Laitinen, Jaana Pouta, Anneli Zitting, Paavo McArdle, Wendy L. Kroemer, Heyo K. Voelker, Uwe Voelzke, Henry Glazer, Nicole L. Taylor, Kent D. Harris, Tamara B. Alavere, Helene Haller, Toomas Keis, Aime Tammesoo, Mari-Liis Aulchenko, Yurii Barroso, Ines Khaw, Kay-Tee Galan, Pilar Hercberg, Serge Lathrop, Mark Eyheramendy, Susana Org, Elin Sober, Siim Lu, Xiaowen Nolte, Ilja M. Penninx, Brenda W. Corre, Tanguy Masciullo, Corrado Sala, Cinzia Groop, Leif Voight, Benjamin F. Melander, Olle O'Donnell, Christopher J. Salomaa, Veikko d'Adamo, Adamo Pio Fabretto, Antonella Faletra, Flavio Ulivi, Sheila Del Greco, Fabiola M. Facheris, Maurizio Collins, Francis S. Bergman, Richard N. Beilby, John P. Hung, Joseph Musk, A. William Mangino, Massimo Shin, So-Youn Soranzo, Nicole Watkins, Hugh Goel, Anuj Hamsten, Anders Gider, Pierre Loitfelder, Marisa Zeginigg, Marion Hernandez, Dena Najjar, Samer S. Navarro, Pau Wild, Sarah H. Corsi, Anna Maria Singleton, Andrew de Geus, Eco J. C. Willemsen, Gonneke Parker, Alex N. Rose, Lynda M. Buckley, Brendan Stott, David Orru, Marco Uda, Manuela van der Klauw, Melanie M. Zhang, Weihua Li, Xinzhong Scott, James Chen, Yii-Der Ida Burke, Gregory L. Kahonen, Mika Viikari, Jorma Doering, Angela Meitinger, Thomas Davies, Gail Starr, John M. Emilsson, Valur Plump, Andrew Lindeman, Jan H. 't Hoen, Peter A. C. Koenig, Inke R. Felix, Janine F. Clarke, Robert Hopewell, Jemma C. Ongen, Halit Breteler, Monique Debette, Stephanie DeStefano, Anita L. Fornage, Myriam Mitchell, Gary F. Smith, Nicholas L. Holm, Hilma Stefansson, Kari Thorleifsson, Gudmar Thorsteinsdottir, Unnur Samani, Nilesh J. Preuss, Michael Rudan, Igor Hayward, Caroline Deary, Ian J. Wichmann, H-Erich Raitakari, Olli T. Palmas, Walter Kooner, Jaspal S. Stolk, Ronald P. Jukema, J. Wouter Wright, Alan F. Boomsma, Dorret I. Bandinelli, Stefania Gyllensten, Ulf B. Wilson, James F. Ferrucci, Luigi Schmidt, Reinhold Farrall, Martin Spector, Tim D. Palmer, Lyle J. Tuomilehto, Jaakko Pfeufer, Arne Gasparini, Paolo Siscovick, David Altshuler, David Loos, Ruth J. F. Toniolo, Daniela Snieder, Harold Gieger, Christian Meneton, Pierre Wareham, Nicholas J. Oostra, Ben A. Metspalu, Andres Launer, Lenore Rettig, Rainer Strachan, David P. Beckmann, Jacques S. Witteman, Jacqueline C. M. Erdmann, Jeanette van Dijk, Ko Willems Boerwinkle, Eric Boehnke, Michael Ridker, Paul M. Jarvelin, Marjo-Riitta Chakravarti, Aravinda Abecasis, Goncalo R. Gudnason, Vilmundur Newton-Cheh, Christopher Levy, Daniel Munroe, Patricia B. Psaty, Bruce M. Caulfield, Mark J. Rao, Dabeeru C. Tobin, Martin D. Elliott, Paul van Duijn, Cornelia M.
Publication Year :
2011
Abstract
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
Details
Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1235080262
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1038.ng.922