Recombinant expression of insulin C-peptide

The invention relates to a method for the preparation of insulin C-peptide which includes expressing in a host cell of a multimer polypeptide containing copies of the insulin C-peptide, and degradation of the expressed polypeptide for the release of individual copies of the insulin C-peptide. The invention also relates to molecules of the nucleinic acid, to vectors of expression and host cells for the application of this method and to multimer insulin C-polypeptide expressed and degraded in accordance with the method. 21 claims
US 6558924-B1 (2003-05-06)