Pyrazole-inducible proteins in DBA/2 mouse liver bind with high affinity to the 3'-untranslated regions of the mRNAs of coumarin hydroxylase (CYP2A5) and c-jun

An important mechanism in the up-regulation of cytochrome P-450 2A5 (CYP2A5, coumarin hydroxylase, Coh) is the stabilization of the corresponding mRNA; some evidence suggests that proteins binding to CYP2A5 mRNA may be involved in this stabilization. Her
Addresses: Hergenhahn M, Deutsch Krebsforschungszentrum, Div Toxicol & Canc Risk Factors, Neuenheimer Feld 280, D-69120 Heidelberg, Germany. Deutsch Krebsforschungszentrum, Div Toxicol & Canc Risk Factors, D-69120 Heidelberg, Germany. Int Agcy Res Canc