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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Authors :
Lu, Yingchang Day, Felix R Gustafsson, Stefan Buchkovich, Martin L Na, Jianbo Bataille, Veronique Cousminer, Diana L Dastani, Zari Drong, Alexander W Esko, Tõnu Evans, David M Falchi, Mario Feitosa, Mary F Ferreira, Teresa Hedman, Åsa K Haring, Robin Hysi, Pirro G Iles, Mark M Justice, Anne E Kanoni, Stavroula Lagou, Vasiliki Li, Rui Li, Xin Locke, Adam Lu, Chen Mägi, Reedik Perry, John R B Pers, Tune H Qi, Qibin Sanna, Marianna Schmidt, Ellen M Scott, William R Shungin, Dmitry Teumer, Alexander Vinkhuyzen, Anna A E Walker, Ryan W Westra, Harm-Jan Zhang, Mingfeng Zhang, Weihua Zhao, Jing Hua Zhu, Zhihong Afzal, Uzma Ahluwalia, Tarunveer Singh Bakker, Stephan J L Bellis, Claire Bonnefond, Amélie Borodulin, Katja Buchman, Aron S Cederholm, Tommy Choh, Audrey C Choi, Hyung Jin Curran, Joanne E de Groot, Lisette C P G M De Jager, Philip L Dhonukshe-Rutten, Rosalie A M Enneman, Anke W Eury, Elodie Evans, Daniel S Forsen, Tom Friedrich, Nele Fumeron, Frédéric Garcia, Melissa E Gärtner, Simone Han, Bok-Ghee Havulinna, Aki S Hayward, Caroline Hernandez, Dena Hillege, Hans Ittermann, Till Kent, Jack W Kolcic, Ivana Laatikainen, Tiina Lahti, Jari Mateo Leach, Irene Lee, Christine G Lee, Jong-Young Liu, Tian Liu, Youfang Lobbens, Stéphane Loh, Marie Lyytikäinen, Leo-Pekka Medina-Gomez, Carolina Michaëlsson, Karl Nalls, Mike A Nielson, Carrie M Oozageer, Laticia Pascoe, Laura Paternoster, Lavinia Polašek, Ozren Ripatti, Samuli Sarzynski, Mark A Shin, Chan Soo Narančić, Nina Smolej Spira, Dominik Srikanth, Priya Steinhagen-Thiessen, Elisabeth Sung, Yun Ju Swart, Karin M A Taittonen, Leena Tanaka, Toshiko Tikkanen, Emmi van der Velde, Nathalie van Schoor, Natasja M Verweij, Niek Wright, Alan F Yu, Lei Zmuda, Joseph M Eklund, Niina Forrester, Terrence Grarup, Niels Jackson, Anne U Kristiansson, Kati Kuulasmaa, Teemu Kuusisto, Johanna Lichtner, Peter Luan, Jian'an Mahajan, Anubha Männistö, Satu Palmer, Cameron D Ried, Janina S Scott, Robert A Stancáková, Alena Wagner, Peter J Demirkan, Ayse Döring, Angela Gudnason, Vilmundur Kiel, Douglas P Kühnel, Brigitte Mangino, Massimo Mcknight, Barbara Menni, Cristina O'Connell, Jeffrey R Oostra, Ben A Shuldiner, Alan R Song, Kijoung Vandenput, Liesbeth van Duijn, Cornelia M Vollenweider, Peter White, Charles C Boehnke, Michael Boettcher, Yvonne Cooper, Richard S Forouhi, Nita G Gieger, Christian Grallert, Harald Hingorani, Aroon Jørgensen, Torben Jousilahti, Pekka Kivimaki, Mika Kumari, Meena Laakso, Markku Langenberg, Claudia Linneberg, Allan Luke, Amy Mckenzie, Colin A Palotie, Aarno Pedersen, Oluf Peters, Annette Strauch, Konstantin Tayo, Bamidele O Wareham, Nicholas J Bennett, David A Bertram, Lars Blangero, John Blüher, Matthias Bouchard, Claude Campbell, Harry Cho, Nam H Cummings, Steven R Czerwinski, Stefan A Demuth, Ilja Eckardt, Rahel Eriksson, Johan G Ferrucci, Luigi Franco, Oscar H Froguel, Philippe Gansevoort, Ron T Hansen, Torben Harris, Tamara B Hastie, Nicholas Heliövaara, Markku Hofman, Albert Jordan, Joanne M Jula, Antti Kähönen, Mika Kajantie, Eero Knekt, Paul B Koskinen, Seppo Kovacs, Peter Lehtimäki, Terho Lind, Lars Liu, Yongmei Orwoll, Eric S Osmond, Clive Perola, Markus Pérusse, Louis Raitakari, Olli T Rankinen, Tuomo Rao, D C Rice, Treva K Rivadeneira, Fernando Rudan, Igor Salomaa, Veikko Sørensen, Thorkild I A Stumvoll, Michael Tönjes, Anke Towne, Bradford Tranah, Gregory J Tremblay, Angelo Uitterlinden, André G van der Harst, Pim Vartiainen, Erkki Viikari, Jorma S Vitart, Veronique Vohl, Marie-Claude Völzke, Henry Walker, Mark Wallaschofski, Henri Wild, Sarah Wilson, James F Yengo, Loïc Bishop, D Timothy Borecki, Ingrid B Chambers, John C Cupples, L Adrienne Dehghan, Abbas Deloukas, Panos Fatemifar, Ghazaleh Fox, Caroline Furey, Terrence S Franke, Lude Han, Jiali Hunter, David J Karjalainen, Juha Karpe, Fredrik Kaplan, Robert C Kooner, Jaspal S McCarthy, Mark I Murabito, Joanne M Morris, Andrew P Bishop, Julia A N North, Kari E Ohlsson, Claes Ong, Ken K Prokopenko, Inga Richards, J Brent Schadt, Eric E Spector, Tim D Widén, Elisabeth Willer, Cristen J Yang, Jian Ingelsson, Erik Mohlke, Karen L Hirschhorn, Joel N Pospisilik, John Andrew Zillikens, M Carola Lindgren, Cecilia Kilpeläinen, Tuomas Oskari Loos, Ruth J F Lu, Yingchang Day, Felix R Gustafsson, Stefan Buchkovich, Martin L Na, Jianbo Bataille, Veronique Cousminer, Diana L Dastani, Zari Drong, Alexander W Esko, Tõnu Evans, David M Falchi, Mario Feitosa, Mary F Ferreira, Teresa Hedman, Åsa K Haring, Robin Hysi, Pirro G Iles, Mark M Justice, Anne E Kanoni, Stavroula Lagou, Vasiliki Li, Rui Li, Xin Locke, Adam Lu, Chen Mägi, Reedik Perry, John R B Pers, Tune H Qi, Qibin Sanna, Marianna Schmidt, Ellen M Scott, William R Shungin, Dmitry Teumer, Alexander Vinkhuyzen, Anna A E Walker, Ryan W Westra, Harm-Jan Zhang, Mingfeng Zhang, Weihua Zhao, Jing Hua Zhu, Zhihong Afzal, Uzma Ahluwalia, Tarunveer Singh Bakker, Stephan J L Bellis, Claire Bonnefond, Amélie Borodulin, Katja Buchman, Aron S Cederholm, Tommy Choh, Audrey C Choi, Hyung Jin Curran, Joanne E de Groot, Lisette C P G M De Jager, Philip L Dhonukshe-Rutten, Rosalie A M Enneman, Anke W Eury, Elodie Evans, Daniel S Forsen, Tom Friedrich, Nele Fumeron, Frédéric Garcia, Melissa E Gärtner, Simone Han, Bok-Ghee Havulinna, Aki S Hayward, Caroline Hernandez, Dena Hillege, Hans Ittermann, Till Kent, Jack W Kolcic, Ivana Laatikainen, Tiina Lahti, Jari Mateo Leach, Irene Lee, Christine G Lee, Jong-Young Liu, Tian Liu, Youfang Lobbens, Stéphane Loh, Marie Lyytikäinen, Leo-Pekka Medina-Gomez, Carolina Michaëlsson, Karl Nalls, Mike A Nielson, Carrie M Oozageer, Laticia Pascoe, Laura Paternoster, Lavinia Polašek, Ozren Ripatti, Samuli Sarzynski, Mark A Shin, Chan Soo Narančić, Nina Smolej Spira, Dominik Srikanth, Priya Steinhagen-Thiessen, Elisabeth Sung, Yun Ju Swart, Karin M A Taittonen, Leena Tanaka, Toshiko Tikkanen, Emmi van der Velde, Nathalie van Schoor, Natasja M Verweij, Niek Wright, Alan F Yu, Lei Zmuda, Joseph M Eklund, Niina Forrester, Terrence Grarup, Niels Jackson, Anne U Kristiansson, Kati Kuulasmaa, Teemu Kuusisto, Johanna Lichtner, Peter Luan, Jian'an Mahajan, Anubha Männistö, Satu Palmer, Cameron D Ried, Janina S Scott, Robert A Stancáková, Alena Wagner, Peter J Demirkan, Ayse Döring, Angela Gudnason, Vilmundur Kiel, Douglas P Kühnel, Brigitte Mangino, Massimo Mcknight, Barbara Menni, Cristina O'Connell, Jeffrey R Oostra, Ben A Shuldiner, Alan R Song, Kijoung Vandenput, Liesbeth van Duijn, Cornelia M Vollenweider, Peter White, Charles C Boehnke, Michael Boettcher, Yvonne Cooper, Richard S Forouhi, Nita G Gieger, Christian Grallert, Harald Hingorani, Aroon Jørgensen, Torben Jousilahti, Pekka Kivimaki, Mika Kumari, Meena Laakso, Markku Langenberg, Claudia Linneberg, Allan Luke, Amy Mckenzie, Colin A Palotie, Aarno Pedersen, Oluf Peters, Annette Strauch, Konstantin Tayo, Bamidele O Wareham, Nicholas J Bennett, David A Bertram, Lars Blangero, John Blüher, Matthias Bouchard, Claude Campbell, Harry Cho, Nam H Cummings, Steven R Czerwinski, Stefan A Demuth, Ilja Eckardt, Rahel Eriksson, Johan G Ferrucci, Luigi Franco, Oscar H Froguel, Philippe Gansevoort, Ron T Hansen, Torben Harris, Tamara B Hastie, Nicholas Heliövaara, Markku Hofman, Albert Jordan, Joanne M Jula, Antti Kähönen, Mika Kajantie, Eero Knekt, Paul B Koskinen, Seppo Kovacs, Peter Lehtimäki, Terho Lind, Lars Liu, Yongmei Orwoll, Eric S Osmond, Clive Perola, Markus Pérusse, Louis Raitakari, Olli T Rankinen, Tuomo Rao, D C Rice, Treva K Rivadeneira, Fernando Rudan, Igor Salomaa, Veikko Sørensen, Thorkild I A Stumvoll, Michael Tönjes, Anke Towne, Bradford Tranah, Gregory J Tremblay, Angelo Uitterlinden, André G van der Harst, Pim Vartiainen, Erkki Viikari, Jorma S Vitart, Veronique Vohl, Marie-Claude Völzke, Henry Walker, Mark Wallaschofski, Henri Wild, Sarah Wilson, James F Yengo, Loïc Bishop, D Timothy Borecki, Ingrid B Chambers, John C Cupples, L Adrienne Dehghan, Abbas Deloukas, Panos Fatemifar, Ghazaleh Fox, Caroline Furey, Terrence S Franke, Lude Han, Jiali Hunter, David J Karjalainen, Juha Karpe, Fredrik Kaplan, Robert C Kooner, Jaspal S McCarthy, Mark I Murabito, Joanne M Morris, Andrew P Bishop, Julia A N North, Kari E Ohlsson, Claes Ong, Ken K Prokopenko, Inga Richards, J Brent Schadt, Eric E Spector, Tim D Widén, Elisabeth Willer, Cristen J Yang, Jian Ingelsson, Erik Mohlke, Karen L Hirschhorn, Joel N Pospisilik, John Andrew Zillikens, M Carola Lindgren, Cecilia Kilpeläinen, Tuomas Oskari Loos, Ruth J F
Publication Year :
2016
Abstract
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Details
Database :
OAIster
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1233942684
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1038.ncomms10495