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Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
- Publication Year :
- 2008
-
Abstract
- We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.
Details
- Database :
- OAIster
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1233432825
- Document Type :
- Electronic Resource
- Full Text :
- https://doi.org/10.1038.ng.2007.52