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Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts

Authors :
Fisiología
Fisiologia
Silventoinen, Karri
Jelenkovic Moreno, Aline
Sund, Reijo
Latvala, Antti
Honda, Chika
Inui, Fujio
Tomizawa, Rie
Watanabe, Mikio
Sakai, Norio
Rebato Ochoa, Esther Matilde
Busjahn, Andreas
Tyler, Jessica
Hopper, John L.
Ordoñana Martín, Juan Ramón
Sánchez Romera, Juan Francisco
Colodro Conde, Lucía
Calais Ferreira, Lucas
Oliveira, Vinicius C.
Ferreira, Pablo H.
Medda, Emanuela
Nisticò, Lorenza
Toccaceli, Virgilia
Derom, Catherine A.
Vlietinck, Robert F.
Loos, Ruth J. F.
Siribaddana, Sisira H.
Hotopf, Matthew
Sumathipala, Athula
Rijsdijk, Fruhling
Duncan, Glen E.
Buchwald, Dedra
Tynelius, Per
Rasmussen, Finn
Tan, Qihua
Zhang, Dongfeng
Pang, Zengchang
Magnusson, Patrik K. E.
Pedersen, Nancy L.
Dahl Aslan, Anna K.
Hwang, Amie E.
Mack, Thomas M.
Krueger, Robert F.
McGue, Matt
Pahlen, Shandell
Brandt, Ingunn
Nilsen, Thomas S.
Harris, Jennifer R.
Martin, Nicholas G.
Medland, Sarah E.
Montgomery, Grant W.
Willemsen, Gonneke
Bartels, Meike
Van Beijsterveldt, Catharina E. M.
Franz, Carol E.
Kremen, William S.
Lyons, Michael J.
Silberg, Judy L.
Maes, Hermine H.
Kandler, Christian
Nelson, Tracy L.
Whitfield, Keith E.
Corley, Robin P.
Huibregtse, Brooke M.
Gatz, Margaret
Butler, David A.
Tarnoki, Adam D.
Tarnoki, David L.
Park, Hang A.
Lee, Jooyeon
Lee, Soo Ji
Sung, Joohon
Yokoyama, Yoshie
Sørensen, Thorkild I. A.
Boomsma, Dorret I.
Kaprio, Jaakko
Fisiología
Fisiologia
Silventoinen, Karri
Jelenkovic Moreno, Aline
Sund, Reijo
Latvala, Antti
Honda, Chika
Inui, Fujio
Tomizawa, Rie
Watanabe, Mikio
Sakai, Norio
Rebato Ochoa, Esther Matilde
Busjahn, Andreas
Tyler, Jessica
Hopper, John L.
Ordoñana Martín, Juan Ramón
Sánchez Romera, Juan Francisco
Colodro Conde, Lucía
Calais Ferreira, Lucas
Oliveira, Vinicius C.
Ferreira, Pablo H.
Medda, Emanuela
Nisticò, Lorenza
Toccaceli, Virgilia
Derom, Catherine A.
Vlietinck, Robert F.
Loos, Ruth J. F.
Siribaddana, Sisira H.
Hotopf, Matthew
Sumathipala, Athula
Rijsdijk, Fruhling
Duncan, Glen E.
Buchwald, Dedra
Tynelius, Per
Rasmussen, Finn
Tan, Qihua
Zhang, Dongfeng
Pang, Zengchang
Magnusson, Patrik K. E.
Pedersen, Nancy L.
Dahl Aslan, Anna K.
Hwang, Amie E.
Mack, Thomas M.
Krueger, Robert F.
McGue, Matt
Pahlen, Shandell
Brandt, Ingunn
Nilsen, Thomas S.
Harris, Jennifer R.
Martin, Nicholas G.
Medland, Sarah E.
Montgomery, Grant W.
Willemsen, Gonneke
Bartels, Meike
Van Beijsterveldt, Catharina E. M.
Franz, Carol E.
Kremen, William S.
Lyons, Michael J.
Silberg, Judy L.
Maes, Hermine H.
Kandler, Christian
Nelson, Tracy L.
Whitfield, Keith E.
Corley, Robin P.
Huibregtse, Brooke M.
Gatz, Margaret
Butler, David A.
Tarnoki, Adam D.
Tarnoki, David L.
Park, Hang A.
Lee, Jooyeon
Lee, Soo Ji
Sung, Joohon
Yokoyama, Yoshie
Sørensen, Thorkild I. A.
Boomsma, Dorret I.
Kaprio, Jaakko
Publication Year :
2020

Abstract

We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural-geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 countries and including 193,518 twins with information on educational attainment at 25 years of age or older. Genetic factors explained the major part of individual differences in educational attainment (heritability: a(2)=0.43; 0.41-0.44), but also environmental variation shared by co-twins was substantial (c(2)=0.31; 0.30-0.33). The proportions of educational variation explained by genetic and shared environmental factors did not differ between Europe, North America and Australia, and East Asia. When restricted to twins 30 years or older to confirm finalized education, the heritability was higher in the older cohorts born in 1900-1949 (a(2)=0.44; 0.41-0.46) than in the later cohorts born in 1950-1989 (a(2)=0.38; 0.36-0.40), with a corresponding lower influence of common environmental factors (c(2)=0.31; 0.29-0.33 and c(2)=0.34; 0.32-0.36, respectively). In conclusion, both genetic and environmental factors shared by co-twins have an important influence on individual differences in educational attainment. The effect of genetic factors on educational attainment has decreased from the cohorts born before to those born after the 1950s.

Details

Database :
OAIster
Notes :
This study was conducted within the CODATwins project. We thank Wendy Cozen, University of Southern California, for sharing data with us. Funding for collaborators: Netherlands Twin Register acknowledges the Netherlands Organization for Scientific Research (NWO) and MagW/ZonMW grants 904-61-090, 985-10-002, 912-10-020, 904-61-193,480-04-004, 463-06-001, 451-04-034, 400-05-717, Addiction-31160008, Middelgroot-911-09-032, Spinozapremie 56-464-14192; VU University's Institute for Health and Care Research (EMGO+); the European Research Council (ERC - 230374), the Avera Institute, Sioux Falls, South Dakota (USA). Data collection and analyses in Finnish twin cohorts have been supported by ENGAGE - European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007, Grant Agreement Number 201413, National Institute of Alcohol Abuse and Alcoholism (Grants AA-12502, AA-00145, and AA-09203 to R J Rose, the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant Numbers: 213506, 129680), and the Academy of Finland (Grants 100499, 205585, 118555, 141054, 265240, 263278 and 264146 to J Kaprio). Since its origin the East Flanders Prospective Survey has been partly supported by grants from the Fund of Scientific Research, Flanders and Twins, a non-profit Association for Scientific Research in Multiple Births (Belgium). Anthropometric measurements of the Hungarian twins were supported by Medexpert Ltd., Budapest, Hungary. The Murcia Twin Registry is supported by Fundacion Seneca, Regional Agency for Science and Technology, Murcia, Spain (08633/PHCS/08, 15302/PHCS/10 & 19479/PI/14) and Ministry of Science and Innovation, Spain (PSI2009-11560 & PSI2014-56680-R). K Silventoinen is supported by Osaka University's International Joint Research Promotion Program. We acknowledge The Swedish Twin Registry for access to data. The Swedish Twin Registry is managed by Karolinska Institutet and receives funding through the Swedish Research Council under the grant no 2017, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1226408318
Document Type :
Electronic Resource