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Dynamic characterization of blood flow through the cerebral artery circle by magnetic resonance imaging

Authors :
Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
Benítez Iglesias, Raúl
Mata Miquel, Cristian
Rebollo Ayuso, Carlos
Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
Benítez Iglesias, Raúl
Mata Miquel, Cristian
Rebollo Ayuso, Carlos
Publication Year :
2020

Abstract

Pediatric cerebral vascular diseases are still relatively unknown and have severe consequences at prognostic level. There is currently a lack of quantifiable measures to asses the diagnosis of these diseases, and this study aims to stablish dynamic and static biomarkers, based on the speed of the perfusion and the morphology of the main arterial vessels, respectively, to solve this lack. The main objective of the present work is to develop a technique to obtain an isochronal map that shows the perfusion speed of the blood trough the cerebral artery circle. The scope of this project are the pediatric patients suffering from Moyamoya disease and arteriovenous malformations, which form the database of magnetic resonance angiography image sequences, obtained with the TRANCE technique (Philips), that will be studied in this work. The database is provided by the Sant Joan de Déu hospital in Barcelona, and this work is carried out with the supervision and advice of Dr. Josep Munuera. The images have been filtered with a local adaptive filter in the first place to remove the significant amount of noise that some of the images presented. The filter is to be adjusted with two parameters to correctly adapt to the intensity of noise of each image. Then, they are segmented to obtain a binary representation of the arterial vessel structure using a K-means algorithm. The isochronal map is build using the binary representation of the vessel structure at each point of time (each point of time corresponds to a frame in the sequence). Dynamic biomarkers have been extracted from the isochronal map, and morphological biomarkers have been extracted after a binarization and skeletonization of the full arterial vessel structure, which is obtained summing all the frames in a sequence. The isochronal maps has been used once obtained to asses several cases and the biomarkers have been used to compare the effectiveness of a vasoactive drug, acetazolamide, by comparing the biomarkers before and

Details

Database :
OAIster
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1224041986
Document Type :
Electronic Resource