Mortality caused by extended-spectrum beta-lactamase–producing Enterobacteriaceae bacteremia; a case control study: alert to Enterobacteriaceae strains with high minimum inhibitory concentrations of piperacillin/tazobactam

Purpose: The incidence of infections caused by extended spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) has been recently increasing worldwide. ESBL-PE bacteremia has been associated with high mortality and has thus become a clinically critical issue. Accordingly, ESBL-PE strains with low susceptibility to piperacillin/tazobactam (PTZ) are a concern in clinical practice. This study aimed to assess the prognostic factors of patients with bacteremia due to ESBL-PE as well as the antimicrobial susceptibility, particularly to PTZ, among ESBL-PE strains. / Methods: A total of 65 patients with ESBL-PE bacteremia who were admitted to Osaka City University Hospital between January 2011 and April 2017 were enrolled and divided into the survivor group (n=52) and nonsurvivor group (n=13). The medical records of these patients were retrospectively reviewed....