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The time to relapse correlates with the histopathological growth pattern in nodular lymphocyte predominant Hodgkin lymphoma

Authors :
Hartmann, Sylvia
Pluetschow, Annette
Mottok, Anja
Bernd, Heinz-Wolfram
Feller, Alfred C.
Ott, German
Cogliatti, Sergio
Fend, Falko
Quintanilla-Martinez, Leticia
Stein, Harald
Klapper, Wolfram
Moeller, Peter
Rosenwald, Andreas
Engert, Andreas
Hansmann, Martin-Leo
Eichenauer, Dennis A.
Hartmann, Sylvia
Pluetschow, Annette
Mottok, Anja
Bernd, Heinz-Wolfram
Feller, Alfred C.
Ott, German
Cogliatti, Sergio
Fend, Falko
Quintanilla-Martinez, Leticia
Stein, Harald
Klapper, Wolfram
Moeller, Peter
Rosenwald, Andreas
Engert, Andreas
Hansmann, Martin-Leo
Eichenauer, Dennis A.
Publication Year :
2019

Abstract

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) can present with different histopathological growth patterns. The impact of these histopathological growth patterns on relapse characteristics is unknown. We therefore analyzed paired biopsies obtained at initial diagnosis and relapse from 33 NLPHL patients who had received first-line treatment within German Hodgkin Study Group (GHSG) trial protocols, and from a second cohort of 41 relapsed NLPHL patients who had been treated outside GHSG studies. Among the 33 GHSG patients, 21 patients presented with a typical growth pattern at initial diagnosis, whereas 12 patients had a variant histology. The histopathological growth patterns at initial diagnosis and at relapse were consistent in 67% of cases. A variant histology at initial diagnosis was associated with a shorter median time to lymphoma recurrence (2.8 vs 5.2 years; P = .0219). A similar tendency towards a shorter median time to lymphoma recurrence was observed for patients presenting with a variant histology at relapse, irrespective of the growth pattern at initial diagnosis. Results obtained from the 41 NLPHL patients who had been treated outside GHSG studies were comparable (median time to lymphoma recurrence for variant histology vs typical growth pattern at initial diagnosis: 1.5 vs 7.0 years). In conclusion, the histopathological growth pattern remains consistent at relapse in the majority of NLPHL cases, and has major impact on the time of relapse.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1201314787
Document Type :
Electronic Resource