Long-Term Survival, Morbidity, Social Functioning and Risk of Disability in Patients with a Herpes Simplex Virus Type 1 or Type 2 Central Nervous System Infection, Denmark, 2000–2016

Ann-Brit E Hansen,1– 3 Hanne T Vestergaard,4 Ram B Dessau,5 Jacob Bodilsen,6 Nanna S Andersen,7 Lars H Omland,1 Claus B Christiansen,8 Svend Ellermann-Eriksen,9 Lene Nielsen,10 Thomas Benfield,2,3 Henrik T Sørensen,11 Christian Ø Andersen,12 Anne-Mette Lebech,1,3 Niels Obel1,3 1Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 2Department of Infectious Diseases, Amager Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark; 3Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; 4Department of Virus & Microbiological Special Diagnostics, Statens Serum Institute, Copenhagen, Denmark; 5Department of Clinical Microbiology, Slagelse Hospital, Slagelse, Denmark; 6Departments of Infectious Diseases and Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark; 7Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark; 8Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 9Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark; 10Department of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark; 11Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 12Department of Clinical Microbiology, Amager Hvidovre University Hospital, University of Copenhagen, Hvidovre, DenmarkCorrespondence: Ann-Brit E HansenDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen Ø DK-2100, DenmarkTel +45 30299306Email ann-brit.eg.hansen.02@regionh.dkBackground: The long-term prognosis following herpes simplex virus (HSV) central nervous system (CNS) infection is still debated.Patients and Methods: We examined outcomes in all Danish residents who, during 2000– 2016, tested PCR positive for HSV-1 (n=208) or HSV-2 (n=283)