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Long-term Treatment of Teicoplanin for Methicillin-resistant Staphylococcus aureus Sternal Osteomyelitis with Renal Impairment : A Case of High Teicoplanin Trough Levels Maintained by Therapeutic Drug Monitoring
- Publication Year :
- 2016
-
Abstract
- Teicoplanin, a glycopeptide antibiotic for methicillin-resistant Staphylococcus aureus, is recommended for therapeutic drug monitoring during treatment. Maintaining a high trough range of teicoplanin is also recommended for severe infectious disease. However, the optimal dose and interval of treatment for severe renal impairment is unknown. We report a 79-year-old man who received long-term teicoplanin treatment for methicillin-resistant Staphylococcus aureus bacteremia due to postoperative sternal osteomyelitis with renal impairment. Plasma teicoplanin trough levels were maintained at a high range (20-30 μg/mL). Although the patient required long-term teicoplanin treatment, a further decline in renal function was not observed, and blood culture remained negative after the start of treatment. Teicoplanin treatment that is maintained at a high trough level by therapeutic drug monitoring might be beneficial for severe methicillin-resistant Staphylococcus aureus infection accompanied by renal impairment.
Details
- Database :
- OAIster
- Notes :
- Shiohira, Hideo, Nakamatsu, Masashi, Kise, Yuya, Higa, Futoshi, Tateyama, Masao, Hokama, Nobuo, Kuniyoshi, Yukio, Ueda, Shinichiro, Nakamura, Katsunori, Fujita, Jiro
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1180772515
- Document Type :
- Electronic Resource