Back to Search
Start Over
Variabiliteit in farmacokinetiek van intraveneuze paracetamol bij gezonde ouderen
- Publication Year :
- 2019
-
Abstract
- BACKGROUND and OBJECTIVE Paracetamol is the most used analgesic in older people. The physiological changes occurring with ageing influence the pharmacokinetics of paracetamol and its variability. A population pharmacokinetic analysis to describe the pharmacokinetics of intravenous paracetamol in fit older people was performed. Thereafter, simulations were conducted to illustrate target attainment and variability of paracetamol exposure following current dosing regimens (1000 mg q6h, q8h) using steady-state concentration (Css-mean) of 10 mg/L as target for effective analgesia. DESIGN and METHODS A population pharmacokinetic-analysis, using NONMEM 7.2, was performed based on 601 concentrations of paracetamol from 30 fit
Details
- Database :
- OAIster
- Notes :
- application/pdf, Pharmaceutisch Weekblad vol. 154 no. 44, pp. 21-25, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1157012290
- Document Type :
- Electronic Resource