Genetic manipulation of adult-born hippocampal neurons rescues memory in a mouse model of Alzheimer's disease

Richetin et al. demonstrate that retroviral expression of the transcription factor NeuroD1 in neural progenitor cells of the adult mouse hippocampus promotes differentiation, maturation and synaptic integration of newborn granule cells in vivo. When applied to a mouse model of Alzheimer's disease, the gene-targeting strategy abolishes hippocampus-dependent memory deficits