Time-lapse Observation of Stabilized Mitochondrial Membrane Potential in Chemotherapy-induced Granulosa Cell Damage Treated with L-carnitine

Background : Chemotherapy-induced infertility has become problems faced by reproductive-age women receiving chemotherapy and many anticancer drugs mainly affect proliferating cells such as granulosa cells, which support the oocyte. The aims of this study were to investigate mitochondrial membrane potential and to test the protective effect of L-carnitine (LC) in the granulosa cells treated with anticancer drugs. / Methods : Female ICR mice were divided into 5 groups (control, cisplatin, cisplatin+LC, paclitaxel, paclitaxel+LC) and the number of follicles in three sections of ovaries was counted every 100 μm at each development stage....