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The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact

Authors :
van Dessel, L. (Lisanne)
Riet, J. (Job) van
Smits, M. (Minke)
Zhu, Y. (Yanyun)
Hamberg, A.P. (Paul)
Heijden, M.S. (Michiel) van der
Bergman, A.M. (Andries)
Oort, I.M. (Inge) van
Wit, R. (Ronald) de
Voest, E.E. (Emile)
Steeghs, N. (Neeltje)
Yamaguchi, T.N. (Takafumi N.)
Livingstone, J. (Julie)
Boutros, P.C. (Paul C.)
Martens, J.W.M. (John)
Sleijfer, S. (Stefan)
Cuppen, E. (Edwin)
Zwart, W. (Wilbert)
Werken, H.J.G. (Harmen) van de
Mehra, N. (Niven)
Lolkema, M.P. (Martijn)
van Dessel, L. (Lisanne)
Riet, J. (Job) van
Smits, M. (Minke)
Zhu, Y. (Yanyun)
Hamberg, A.P. (Paul)
Heijden, M.S. (Michiel) van der
Bergman, A.M. (Andries)
Oort, I.M. (Inge) van
Wit, R. (Ronald) de
Voest, E.E. (Emile)
Steeghs, N. (Neeltje)
Yamaguchi, T.N. (Takafumi N.)
Livingstone, J. (Julie)
Boutros, P.C. (Paul C.)
Martens, J.W.M. (John)
Sleijfer, S. (Stefan)
Cuppen, E. (Edwin)
Zwart, W. (Wilbert)
Werken, H.J.G. (Harmen) van de
Mehra, N. (Niven)
Lolkema, M.P. (Martijn)
Publication Year :
2019

Abstract

Metastatic castration-resistant prostate cancer (mCRPC) has a highly complex genomic landscape. With the recent development of novel treatments, accurate stratification strategies are needed. Here we present the whole-genome sequencing (WGS) analysis of fresh-frozen metastatic biopsies from 197 mCRPC patients. Using unsupervised clustering based on genomic features, we define eight distinct genomic clusters. We observe potentially clinically relevant genotypes, including microsatellite inst

Details

Database :
OAIster
Notes :
application/pdf, Nature Communications vol. 10 no. 1, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1134976155
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1038.s41467-019-13084-7
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