Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat)

Peptide T (PT), an octapeptide fragment located in the V2 region of the HIV-1 gp120- coating protein, appears to be bene fi cial in the treatment of psoriasis. Our previous investigations suggest that keratinocytes play a key role in conditioning the therapeutic effects of PT in psoriasis. The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN- γ and TNF- α -NHEK activated cells. Moreover, we analysed the interference of PT and its analogues through STAT-3 activation. Our results show that the analogues tested exhibit the bene fi cial biol- ogical effects of PT, suggesting the primary role of keratinocytes upon which PT and the peptido- mimetics act directly, by reducing proin fl ammatory responses. Its reduction appears to be important for therapeutic approach in psoriasis pathogenesis
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Postprint (published version)